DM4
≥98%
- Product Code: 126985
Alias:
Maytansine DM4; N2'-Deacetyl-N2'-(4-Mercapto-4-methyl-1-oxopentyl)-Maytansine
CAS:
796073-69-3
| Molecular Weight: | 780.37 g./mol | Molecular Formula: | C₃₈H₅₄ClN₃O₁₀S |
|---|---|---|---|
| EC Number: | MDL Number: | MFCD28144516 | |
| Melting Point: | 185-187 °C (decomp) | Boiling Point: | 943.2±65.0 °C |
| Density: | 1.29±0.1 g/cm3 | Storage Condition: | 2-8°C, dry, sealed |
Product Description:
DM4 is primarily utilized in the development of antibody-drug conjugates (ADCs) for targeted cancer therapy. It functions as a potent cytotoxic agent that is linked to monoclonal antibodies, which specifically bind to antigens on cancer cells. Once the ADC is internalized by the cancer cell, DM4 is released, disrupting microtubule function and leading to cell death. This approach minimizes damage to healthy tissues, making it a valuable component in precision medicine for treating various cancers, including breast, lung, and lymphoma. Its high potency and targeted delivery enhance the efficacy of cancer treatments while reducing systemic toxicity.
Product Specification:
| Test | Specification |
|---|---|
| Appearance | White To Light Yellow Powder |
| Purity (%) | 97.5-100 |
| Infrared Spectrum | Conforms To Structure |
Sizes / Availability / Pricing:
| Size (g) | Availability | Price | Quantity |
|---|---|---|---|
| 0.001 | 10-20 days | $140.63 |
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| 0.005 | 10-20 days | $431.94 |
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| 0.025 | 10-20 days | $1,499.75 |
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DM4
DM4 is primarily utilized in the development of antibody-drug conjugates (ADCs) for targeted cancer therapy. It functions as a potent cytotoxic agent that is linked to monoclonal antibodies, which specifically bind to antigens on cancer cells. Once the ADC is internalized by the cancer cell, DM4 is released, disrupting microtubule function and leading to cell death. This approach minimizes damage to healthy tissues, making it a valuable component in precision medicine for treating various cancers, including breast, lung, and lymphoma. Its high potency and targeted delivery enhance the efficacy of cancer treatments while reducing systemic toxicity.
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