2'-O-tert-butyldimethylsilyl-N4-benzoyl-cytidine
95%
- Product Code: 40420
CAS:
185398-21-4
| Molecular Weight: | 461.58 g./mol | Molecular Formula: | C₂₂H₃₁N₃O₆Si |
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| Density: | Storage Condition: | 2-8℃ |
Product Description:
This compound is primarily utilized in the synthesis of modified nucleosides, which are crucial intermediates in the development of oligonucleotides for therapeutic and research purposes. Its application is significant in the field of nucleic acid chemistry, where it serves as a protected form of cytidine, ensuring selective reactivity during chemical reactions. The tert-butyldimethylsilyl (TBDMS) group provides stability and protection for the 2'-hydroxyl group, while the benzoyl group safeguards the exocyclic amine, allowing for precise control in the construction of RNA or DNA analogs. This compound is particularly valuable in the production of antisense oligonucleotides, siRNA, and other nucleic acid-based therapeutics, where specific modifications are required to enhance stability, binding affinity, or cellular uptake. Its role in enabling the synthesis of complex nucleotide structures makes it indispensable in both academic research and pharmaceutical development.
Sizes / Availability / Pricing:
| Size (g) | Availability | Price | Quantity |
|---|---|---|---|
| 0.025 | 10-20 days | ฿2,880.00 |
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| 0.100 | 10-20 days | ฿10,665.00 |
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2'-O-tert-butyldimethylsilyl-N4-benzoyl-cytidine
This compound is primarily utilized in the synthesis of modified nucleosides, which are crucial intermediates in the development of oligonucleotides for therapeutic and research purposes. Its application is significant in the field of nucleic acid chemistry, where it serves as a protected form of cytidine, ensuring selective reactivity during chemical reactions. The tert-butyldimethylsilyl (TBDMS) group provides stability and protection for the 2'-hydroxyl group, while the benzoyl group safeguards the exocyclic amine, allowing for precise control in the construction of RNA or DNA analogs. This compound is particularly valuable in the production of antisense oligonucleotides, siRNA, and other nucleic acid-based therapeutics, where specific modifications are required to enhance stability, binding affinity, or cellular uptake. Its role in enabling the synthesis of complex nucleotide structures makes it indispensable in both academic research and pharmaceutical development.
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