Sacubitril
98%
- Product Code: 51123
CAS:
149709-62-6
| Molecular Weight: | 411.49 g./mol | Molecular Formula: | C₂₄H₂₉NO₅ |
|---|---|---|---|
| EC Number: | MDL Number: | MFCD00920862 | |
| Melting Point: | Boiling Point: | ||
| Density: | Storage Condition: | room temperature, dry |
Product Description:
Sacubitril is primarily used in combination with valsartan as a treatment for heart failure, specifically for patients with reduced ejection fraction (HFrEF). This combination, known as sacubitril/valsartan, works by inhibiting neprilysin and blocking the angiotensin II receptor, which helps to relax blood vessels, reduce sodium retention, and decrease the strain on the heart. It is often prescribed to improve symptoms, enhance quality of life, and reduce the risk of hospitalization and cardiovascular death in patients with chronic heart failure. The therapy is typically recommended for patients who remain symptomatic despite standard treatments like ACE inhibitors or beta-blockers. Regular monitoring of kidney function and potassium levels is essential during its use to manage potential side effects.
Product Specification:
| Test | Specification |
|---|---|
| APPEARANCE | solid |
| PURITY | 97.5-100 |
| Infrared spectrum | Conforms to Structure |
| NMR | Conforms to Structure |
Sizes / Availability / Pricing:
| Size (g) | Availability | Price | Quantity |
|---|---|---|---|
| 0.250 | 10-20 days | ฿3,850.00 |
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| 1.000 | 10-20 days | ฿10,000.00 |
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Sacubitril
Sacubitril is primarily used in combination with valsartan as a treatment for heart failure, specifically for patients with reduced ejection fraction (HFrEF). This combination, known as sacubitril/valsartan, works by inhibiting neprilysin and blocking the angiotensin II receptor, which helps to relax blood vessels, reduce sodium retention, and decrease the strain on the heart. It is often prescribed to improve symptoms, enhance quality of life, and reduce the risk of hospitalization and cardiovascular death in patients with chronic heart failure. The therapy is typically recommended for patients who remain symptomatic despite standard treatments like ACE inhibitors or beta-blockers. Regular monitoring of kidney function and potassium levels is essential during its use to manage potential side effects.
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