α-MaleiMidopropionyl-ω-succiniMidyl-12(ethylene glycol)
95%
- Product Code: 61957
Alias:
Maleimide-PEG12-NHS Ester; Maleimide-NH-PEG12-CH2CH2COONHS Ester; Maleimide-PEG12-NHS Ester
CAS:
756525-92-5
| Molecular Weight: | 865.92 g./mol | Molecular Formula: | C₃₈H₆₃N₃O₁₉ |
|---|---|---|---|
| EC Number: | MDL Number: | ||
| Melting Point: | Boiling Point: | ||
| Density: | Storage Condition: | -20°C |
Product Description:
Used in bioconjugation and drug delivery systems, it serves as a linker molecule to connect biomolecules like proteins, peptides, or antibodies with therapeutic agents. Its polyethylene glycol (PEG) segment enhances solubility and reduces immunogenicity, making it suitable for targeted therapies. The maleimide group reacts with thiols, enabling stable conjugation with cysteine residues in proteins, while the succinimidyl ester reacts with amines, facilitating attachment to amino groups. This dual functionality allows precise and efficient coupling in the development of antibody-drug conjugates (ADCs) and other biopharmaceuticals. Its application is particularly valuable in cancer therapy, where it helps deliver cytotoxic drugs specifically to tumor cells, minimizing off-target effects. Additionally, it is used in diagnostic tools for labeling and imaging purposes.
Product Specification:
| Test | Specification |
|---|---|
| APPEARANCE | White to off-white or light-yellow solid |
| PURITY | 94.5-100 |
| Infrared spectrum | Conforms to Structure |
| NMR | Conforms to Structure |
Sizes / Availability / Pricing:
| Size (g) | Availability | Price | Quantity |
|---|---|---|---|
| 0.250 | 10-20 days | $1,539.43 |
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α-MaleiMidopropionyl-ω-succiniMidyl-12(ethylene glycol)
Used in bioconjugation and drug delivery systems, it serves as a linker molecule to connect biomolecules like proteins, peptides, or antibodies with therapeutic agents. Its polyethylene glycol (PEG) segment enhances solubility and reduces immunogenicity, making it suitable for targeted therapies. The maleimide group reacts with thiols, enabling stable conjugation with cysteine residues in proteins, while the succinimidyl ester reacts with amines, facilitating attachment to amino groups. This dual functionality allows precise and efficient coupling in the development of antibody-drug conjugates (ADCs) and other biopharmaceuticals. Its application is particularly valuable in cancer therapy, where it helps deliver cytotoxic drugs specifically to tumor cells, minimizing off-target effects. Additionally, it is used in diagnostic tools for labeling and imaging purposes.
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