N-Succinimidyl 3-Maleimidobenzoate
≥98%
- Product Code: 94476
CAS:
58626-38-3
| Molecular Weight: | 314.25 g./mol | Molecular Formula: | C₁₅H₁₀N₂O₆ |
|---|---|---|---|
| EC Number: | MDL Number: | MFCD00005514 | |
| Melting Point: | 178-183°C | Boiling Point: | |
| Density: | Storage Condition: | 2-8°C |
Product Description:
Used as a heterobifunctional crosslinker in bioconjugation, it facilitates the attachment of proteins, peptides, or other biomolecules to surfaces or other molecules. The maleimide group reacts with thiols (-SH) in cysteine residues, while the NHS ester group reacts with primary amines (-NH2), enabling precise and stable conjugation. It is particularly useful in antibody-drug conjugates (ADCs), where it links antibodies to cytotoxic drugs for targeted cancer therapy. Additionally, it is employed in immobilizing biomolecules on solid supports for diagnostic assays, biosensors, and research applications. Its stability and efficiency make it a valuable tool in biochemistry and biopharmaceutical development.
Product Specification:
| Test | Specification |
|---|---|
| PURITYHPLC | 97.5 100% |
| PURITYWITH TOTAL NITROGEN | 97.5 100% |
| MELTING POINT | 178 183? |
Sizes / Availability / Pricing:
| Size (g) | Availability | Price | Quantity |
|---|---|---|---|
| 0.100 | 10-20 days | ฿1,980.00 |
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| 0.500 | 10-20 days | ฿4,860.00 |
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| 1.000 | 10-20 days | ฿8,990.00 |
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N-Succinimidyl 3-Maleimidobenzoate
Used as a heterobifunctional crosslinker in bioconjugation, it facilitates the attachment of proteins, peptides, or other biomolecules to surfaces or other molecules. The maleimide group reacts with thiols (-SH) in cysteine residues, while the NHS ester group reacts with primary amines (-NH2), enabling precise and stable conjugation. It is particularly useful in antibody-drug conjugates (ADCs), where it links antibodies to cytotoxic drugs for targeted cancer therapy. Additionally, it is employed in immobilizing biomolecules on solid supports for diagnostic assays, biosensors, and research applications. Its stability and efficiency make it a valuable tool in biochemistry and biopharmaceutical development.
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