N-Succinimidyl 4-(4-Maleimidophenyl)butyrate
≥97%
- Product Code: 94477
CAS:
79886-55-8
| Molecular Weight: | 356.33 g./mol | Molecular Formula: | C₁₈H₁₆N₂O₆ |
|---|---|---|---|
| EC Number: | MDL Number: | MFCD00054961 | |
| Melting Point: | 129-133°C | Boiling Point: | |
| Density: | Storage Condition: | -20°C |
Product Description:
This compound is widely used as a heterobifunctional crosslinker in bioconjugation applications. It is particularly valuable for linking proteins, peptides, or antibodies to other molecules, such as fluorescent dyes, enzymes, or solid supports. The maleimide group reacts specifically with thiol groups (-SH) in cysteine residues, while the N-hydroxysuccinimide (NHS) ester group reacts with primary amines (-NH2) in lysine residues or at the N-terminus of proteins. This dual reactivity allows for the creation of stable, covalent bonds between biomolecules, making it essential in the development of antibody-drug conjugates (ADCs), diagnostic assays, and targeted drug delivery systems. Its application is also prominent in the study of protein-protein interactions and the immobilization of proteins for biosensor development.
Product Specification:
| Test | Specification |
|---|---|
| APPEARANCE | Very pale yellow - Pale yellow green Crystal - Powder |
| PURITY | 96.5-100 |
| Infrared spectrum | Conforms to Structure |
Sizes / Availability / Pricing:
| Size (g) | Availability | Price | Quantity |
|---|---|---|---|
| 0.010 | 10-20 days | ฿4,220.00 |
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| 0.025 | 10-20 days | ฿8,400.00 |
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N-Succinimidyl 4-(4-Maleimidophenyl)butyrate
This compound is widely used as a heterobifunctional crosslinker in bioconjugation applications. It is particularly valuable for linking proteins, peptides, or antibodies to other molecules, such as fluorescent dyes, enzymes, or solid supports. The maleimide group reacts specifically with thiol groups (-SH) in cysteine residues, while the N-hydroxysuccinimide (NHS) ester group reacts with primary amines (-NH2) in lysine residues or at the N-terminus of proteins. This dual reactivity allows for the creation of stable, covalent bonds between biomolecules, making it essential in the development of antibody-drug conjugates (ADCs), diagnostic assays, and targeted drug delivery systems. Its application is also prominent in the study of protein-protein interactions and the immobilization of proteins for biosensor development.
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