N-Succinimidyl 6-[[4-(N-Maleimidomethyl)cyclohexyl]carboxamido]hexanoate
≥98%
- Product Code: 94484
CAS:
125559-00-4
| Molecular Weight: | 447.49 g./mol | Molecular Formula: | C₂₂H₂₉N₃O₇ |
|---|---|---|---|
| EC Number: | MDL Number: | MFCD01863459 | |
| Melting Point: | 180-184°C | Boiling Point: | |
| Density: | Storage Condition: | -20°C |
Product Description:
This compound is widely used in bioconjugation and protein labeling applications due to its bifunctional nature. It serves as a crosslinker, enabling the attachment of biomolecules such as antibodies, peptides, or proteins to other molecules or surfaces. The succinimidyl ester group reacts with primary amines, typically found in lysine residues or the N-terminus of proteins, while the maleimide group selectively reacts with thiol groups, such as those in cysteine residues. This makes it particularly useful in the development of antibody-drug conjugates (ADCs), where it facilitates the precise linkage of cytotoxic drugs to antibodies for targeted cancer therapy. Additionally, it is employed in the preparation of immobilized enzymes for biosensors or diagnostic assays, ensuring stable and specific binding. Its cyclohexyl spacer enhances flexibility and reduces steric hindrance, improving the efficiency of conjugation reactions.
Product Specification:
| Test | Specification |
|---|---|
| APPEARANCE | Light yellow powder |
| PURITY | 97.5-100 |
| Infrared spectrum | Conforms to Structure |
Sizes / Availability / Pricing:
| Size (g) | Availability | Price | Quantity |
|---|---|---|---|
| 0.005 | 10-20 days | ฿5,250.00 |
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N-Succinimidyl 6-[[4-(N-Maleimidomethyl)cyclohexyl]carboxamido]hexanoate
This compound is widely used in bioconjugation and protein labeling applications due to its bifunctional nature. It serves as a crosslinker, enabling the attachment of biomolecules such as antibodies, peptides, or proteins to other molecules or surfaces. The succinimidyl ester group reacts with primary amines, typically found in lysine residues or the N-terminus of proteins, while the maleimide group selectively reacts with thiol groups, such as those in cysteine residues. This makes it particularly useful in the development of antibody-drug conjugates (ADCs), where it facilitates the precise linkage of cytotoxic drugs to antibodies for targeted cancer therapy. Additionally, it is employed in the preparation of immobilized enzymes for biosensors or diagnostic assays, ensuring stable and specific binding. Its cyclohexyl spacer enhances flexibility and reduces steric hindrance, improving the efficiency of conjugation reactions.
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