Fmoc-Val-Cit-PAB-OH
≥98%
- Product Code: 96229
CAS:
159858-22-7
| Molecular Weight: | 601.7 g./mol | Molecular Formula: | C₃₃H₃₉N₅O₆ |
|---|---|---|---|
| EC Number: | MDL Number: | MFCD22417106 | |
| Melting Point: | Boiling Point: | ||
| Density: | Storage Condition: | -20°C |
Product Description:
Used in the synthesis of antibody-drug conjugates (ADCs), particularly as a linker-payload component. It facilitates the targeted delivery of cytotoxic agents to cancer cells, enhancing therapeutic efficacy while minimizing off-target effects. The Fmoc group protects the amino acid during synthesis, while the Val-Cit dipeptide sequence is cleavable by cathepsin B, an enzyme overexpressed in tumor cells. The PAB-OH moiety ensures stable attachment of the payload until it reaches the target site. This chemical is critical in developing precision cancer therapies, enabling controlled release of drugs within tumor environments.
Product Specification:
| Test | Specification |
|---|---|
| APPEARANCE | White to Very pale yellow Crystal to Powder |
| PURITY | 97.5-100 |
| Infrared spectrum | Conforms to Structure |
| NMR | Conforms to Structure |
Sizes / Availability / Pricing:
| Size (g) | Availability | Price | Quantity |
|---|---|---|---|
| 0.250 | 10-20 days | ฿1,060.00 |
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| 1.000 | 10-20 days | ฿2,840.00 |
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| 5.000 | 10-20 days | ฿11,680.00 |
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Fmoc-Val-Cit-PAB-OH
Used in the synthesis of antibody-drug conjugates (ADCs), particularly as a linker-payload component. It facilitates the targeted delivery of cytotoxic agents to cancer cells, enhancing therapeutic efficacy while minimizing off-target effects. The Fmoc group protects the amino acid during synthesis, while the Val-Cit dipeptide sequence is cleavable by cathepsin B, an enzyme overexpressed in tumor cells. The PAB-OH moiety ensures stable attachment of the payload until it reaches the target site. This chemical is critical in developing precision cancer therapies, enabling controlled release of drugs within tumor environments.
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