acne treatment technology developed From the results of the research it was discovered that Restoring the protective layer of the skin (skin-barrier) in combination with acne treatment with the former technique of killing acne bacteria (P. Acnes) will help the treatment to be more effective than other techniques, as well as provide sustainable results.

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Expiration: 09/2024 (Lot: T504F5)

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AcnePLEX™ Acne Treatment Technology developed From the results of the research it was discovered that Restoring the protective layer of the skin (skin-barrier) in combination with acne treatment with the old technique of killing acne bacteria (P. Acnes) will help the treatment to be more effective than other techniques as well as to provide sustainable results. The sustained effect of acne treatment when used continuously for at least 60 days, twice daily, is the hallmark of AcnePLEX™ compared to other acne-fighting ingredients or medications.


AcnePLEX™ Mechanism of Action

1. Restores the balance of the skin's protective barrier. (skin-barrier) with ceramides and phytosphingosine which is a natural component of the skin layer


According to research, the levels of ceramides and phytosphingosine is low in acne-prone skin with cause (1) the level of Ceramides and phytosphingosine enough of the skin It will help the natural skin cell turnover mechanism. can work well natural skin cell turnover It's a very important process. to reduce the likelihood of comedone clotting, which is the starting point of acne (2) phytosphingosine natural skin act as anti-inflammatory and anti-bacteria is therefore of paramount importance In the process of fighting acne infection P.Acnes from research found. when the skin is level Normal phytosphingosine, acne formation. as well as the occurrence of inflammation and become acne, difficult to do Maiden


2. Royal Jelly Extract (10-hydroxydecanoic acid) acts as an anti-bacteria. which until now There is a large amount of research on the efficacy of anti-bacteria As a result, the growth of acne P.Acnes is more difficult.


3. Salicylic Acid is considered a standard component that It is medically accepted that it can help treat acne well. Effective in killing acne And exfoliate to help reduce the chance of clogging of comedone, but usually there is a limitation of use. with a skin-irritating appearance and when an imbalance of skin-barrier occurs, new acne can occur. which was modified to solve this problem in AcnePLEX™ with a balanced composition that both help strengthen the skin's protective barrier along with acne treatment

Maiden Maiden



Recommendations for formula development using AcnePLEX™ as an ingredient

1. AcnePLEX™ was developed to be positively charged. to be able to stick on the skin as well and have a long-lasting effect But there is a limitation in compatibility with formulas that contain anionic cream maker or gel maker. in formulas that want to achieve viscosity Is it a gel or cream Only non-ionic gel maker must be used (e.g. HEC , HPMC )

2. AcnePLEX™ may produce white foam when applied to the skin. therefore recommended to use X-Foam to prevent foaming in the formula.

3. AcnePLEX™ can be used with Other acne ingredients can be treated as normal with AcnePLEX™ where 4% is sufficient to treat common acne breakouts and 5.5% is sufficient to treat severe acne breakouts. without the need for additional ingredients


AcnePLEX™ contains 35% Salicylic Acid.


Example of acne gel formula with AcnePLEX™ 5%

AcnePLEX™ 5%

Hydroxypropyl Methylcellulose 1%

Mild Preserved Eco 1%

X-Foam 0.5%

The rest of the water is 100% complete.


Use: For products that want to treat acne

Mixing method: mix in water Able to withstand heat up to 80 degrees

Usage rate: 1-5.5% (4% for general acne, 5.5% for severe acne)

Product characteristics: clear, yellow liquid

Solubility: can dissolve in water

Storage: can be stored at room temperature But close the lid of the bottle tightly. and protected from sunlight or heat, the product has a shelf life of at least 2 years Maiden


Storage: Store under room temperature. Do not refrigerate.

Shelf Life: 24Months from manufacturing or testing date (Current Lot will expire: 09/2024)

Dosage (Range): 1% - 5.5%

Recommended Dosage: 4%

Mix Method: Add into oil phase. Heat tolerant.

Heat Resistance: Avoid heat above 80C

Stable in pH range: 3.5 - 6.5

Solubility: Water


Product Specification:

Test Specification
Appearance Clear yellowish liquid
General Viscosity 6000-15000cps
Salicylic Acid Assay 31-37%
10-hydroxydecanoic acid Assay 8-10%
Phytosphingosine Assay 3-4%


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