1-(2,6-Dioxopiperidin-3-yl)-5-oxopyrrolidine-3-carboxylic acid
80%
- Product Code: 131620
CAS:
1498191-33-5
| Molecular Weight: | 240.21 g./mol | Molecular Formula: | C₁₀H₁₂N₂O₅ |
|---|---|---|---|
| EC Number: | MDL Number: | MFCD23167038 | |
| Melting Point: | Boiling Point: | 613.6±55.0 °C(Predicted) | |
| Density: | 1.523±0.06 g/cm3(Predicted) | Storage Condition: | 2-8°C, Sealed, Inert Gas |
Product Description:
Used primarily in pharmaceutical research as a key intermediate in the synthesis of immunomodulatory drugs, particularly those related to thalidomide analogs. It plays a critical role in the development of targeted protein degraders such as PROTACs, where it serves as a ligand for cereblon (CRBN), a component of the E3 ubiquitin ligase complex. By recruiting cereblon, this compound enables the selective degradation of disease-related proteins, making it valuable in oncology and inflammatory disease research. Its structure allows for chemical modifications that enhance binding affinity, selectivity, and pharmacokinetic properties in drug candidates.
Sizes / Availability / Pricing:
| Size | Availability | Price | Quantity |
|---|---|---|---|
| 100mg | 10-20 days | ฿5,800.00 |
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| 250mg | 10-20 days | ฿9,850.00 |
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| 1g | 10-20 days | ฿26,600.00 |
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1-(2,6-Dioxopiperidin-3-yl)-5-oxopyrrolidine-3-carboxylic acid
Used primarily in pharmaceutical research as a key intermediate in the synthesis of immunomodulatory drugs, particularly those related to thalidomide analogs. It plays a critical role in the development of targeted protein degraders such as PROTACs, where it serves as a ligand for cereblon (CRBN), a component of the E3 ubiquitin ligase complex. By recruiting cereblon, this compound enables the selective degradation of disease-related proteins, making it valuable in oncology and inflammatory disease research. Its structure allows for chemical modifications that enhance binding affinity, selectivity, and pharmacokinetic properties in drug candidates.
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