3-(5-Bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione
98%
- Product Code: 149828
CAS:
1010100-26-1
| Molecular Weight: | 323.14 g./mol | Molecular Formula: | C₁₃H₁₁BrN₂O₃ |
|---|---|---|---|
| EC Number: | MDL Number: | MFCD32263142 | |
| Melting Point: | Boiling Point: | ||
| Density: | Storage Condition: | Room temperature, airtight, dry |
Product Description:
Used as a key intermediate in the synthesis of targeted protein degradation therapeutics, particularly in the development of cereblon E3 ligase modulators. Its structure enables selective binding to cereblon, facilitating the degradation of disease-related proteins. This makes it valuable in research for anticancer drugs, especially in hematological malignancies like multiple myeloma. It is also employed in the creation of PROTACs (proteolysis-targeting chimeras), where it serves as the E3 ligase recruiting moiety. Due to its bromo functional group, it allows for further chemical modifications through cross-coupling reactions, enhancing its utility in medicinal chemistry and drug discovery.
Product Specification:
| Test | Specification |
|---|---|
| Appearance | Off-white to gray Solid |
| Purity (%) | 97.5-100 |
| Infrared Spectrum | Conforms to Structure |
| NMR | Conforms to Structure |
Sizes / Availability / Pricing:
| Size | Availability | Price | Quantity |
|---|---|---|---|
| 0.250 | 10-20 days | $31.09 |
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| 1.000 | 10-20 days | $93.77 |
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| 5.000 | 10-20 days | $279.77 |
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| 25.000 | 10-20 days | $1,322.68 |
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3-(5-Bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione
Used as a key intermediate in the synthesis of targeted protein degradation therapeutics, particularly in the development of cereblon E3 ligase modulators. Its structure enables selective binding to cereblon, facilitating the degradation of disease-related proteins. This makes it valuable in research for anticancer drugs, especially in hematological malignancies like multiple myeloma. It is also employed in the creation of PROTACs (proteolysis-targeting chimeras), where it serves as the E3 ligase recruiting moiety. Due to its bromo functional group, it allows for further chemical modifications through cross-coupling reactions, enhancing its utility in medicinal chemistry and drug discovery.
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| Heat Resistance | - |
| Stable in pH range | - |
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