4-Chloro-7-fluoro-6-nitroquinazoline
98%
- Product Code: 163781
CAS:
162012-70-6
| Molecular Weight: | 227.58 g./mol | Molecular Formula: | C₈H₃ClFN₃O₂ |
|---|---|---|---|
| EC Number: | MDL Number: | MFCD08063159 | |
| Melting Point: | Boiling Point: | 395 °C | |
| Density: | 1.649 g/cm3 | Storage Condition: | -20°C, Sealed, Dry |
Product Description:
Used as a key intermediate in the synthesis of fluorinated quinazoline-based pharmaceuticals, particularly in the development of kinase inhibitors for cancer treatment. Its electrophilic aromatic ring allows selective substitutions at the 4-position, enabling the attachment of amino or other functional groups to build active drug molecules. Commonly employed in research settings for designing compounds with antitumor, antiviral, and anti-inflammatory activities. The presence of both fluoro and nitro groups enhances reactivity and binding selectivity in biological systems, making it valuable in medicinal chemistry for structure-activity relationship studies.
Product Specification:
| Test | Specification |
|---|---|
| Appearance | Yellow to brown solid powder |
| Purity (%) | 97.5-100 |
| Infrared Spectrum | Conforms to Structure |
| NMR | Conforms to Structure |
Sizes / Availability / Pricing:
| Size | Availability | Price | Quantity |
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| 0.100 | 10-20 days | £55.54 |
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| 0.250 | 10-20 days | £94.39 |
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| 1.000 | 10-20 days | £254.14 |
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| 5.000 | 10-20 days | £665.97 |
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4-Chloro-7-fluoro-6-nitroquinazoline
Used as a key intermediate in the synthesis of fluorinated quinazoline-based pharmaceuticals, particularly in the development of kinase inhibitors for cancer treatment. Its electrophilic aromatic ring allows selective substitutions at the 4-position, enabling the attachment of amino or other functional groups to build active drug molecules. Commonly employed in research settings for designing compounds with antitumor, antiviral, and anti-inflammatory activities. The presence of both fluoro and nitro groups enhances reactivity and binding selectivity in biological systems, making it valuable in medicinal chemistry for structure-activity relationship studies.
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