tert-butyl 1-(4-formylphenyl)-1-oxo-5,8,11,14,17,20,23,26,29,32,35-undecaoxa-2-azaheptatriacontan-37-ylcarbamate
95%
- Product Code: 238456
CAS:
1245813-70-0
| Molecular Weight: | 776.91 g./mol | Molecular Formula: | C₃₇H₆₄N₂O₁₅ |
|---|---|---|---|
| EC Number: | MDL Number: | MFCD20230165 | |
| Melting Point: | Boiling Point: | ||
| Density: | Storage Condition: | -20°C |
Product Description:
Used as a key linker molecule in bioconjugation chemistry, particularly in the development of antibody-drug conjugates (ADCs) and targeted therapeutics. Its aldehyde group enables selective conjugation with aminooxy- or hydrazide-containing biomolecules through stable oxime or hydrazone bond formation. The long polyethylene glycol (PEG) spacer enhances solubility, reduces aggregation, and minimizes steric hindrance, allowing improved binding efficiency and bioavailability. The tert-butyl carbamate (Boc) protected amine provides a handle for further activation or attachment to payloads such as cytotoxic drugs, fluorophores, or peptides. Commonly employed in pharmaceutical research to construct homogeneous conjugates with controlled drug-to-antibody ratios, contributing to enhanced therapeutic index and pharmacokinetic profiles.
Sizes / Availability / Pricing:
| Size | Availability | Price | Quantity |
|---|---|---|---|
| 0.010 | 10-20 days | £944.72 |
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tert-butyl 1-(4-formylphenyl)-1-oxo-5,8,11,14,17,20,23,26,29,32,35-undecaoxa-2-azaheptatriacontan-37-ylcarbamate
Used as a key linker molecule in bioconjugation chemistry, particularly in the development of antibody-drug conjugates (ADCs) and targeted therapeutics. Its aldehyde group enables selective conjugation with aminooxy- or hydrazide-containing biomolecules through stable oxime or hydrazone bond formation. The long polyethylene glycol (PEG) spacer enhances solubility, reduces aggregation, and minimizes steric hindrance, allowing improved binding efficiency and bioavailability. The tert-butyl carbamate (Boc) protected amine provides a handle for further activation or attachment to payloads such as cytotoxic drugs, fluorophores, or peptides. Commonly employed in pharmaceutical research to construct homogeneous conjugates with controlled drug-to-antibody ratios, contributing to enhanced therapeutic index and pharmacokinetic profiles.
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