TCO-PEG3-NHS ester
95%
- Product Code: 238462
CAS:
2141981-88-4
| Molecular Weight: | 470.51 g./mol | Molecular Formula: | C₂₂H₃₄N₂O₉ |
|---|---|---|---|
| EC Number: | MDL Number: | MFCD31811534 | |
| Melting Point: | Boiling Point: | ||
| Density: | Storage Condition: | -20°C, light-proof, inert gas |
Product Description:
Used in bioconjugation to link biomolecules via strain-promoted alkyne-azide cycloaddition (SPAAC), a copper-free click chemistry reaction. The TCO (trans-cyclooctene) group rapidly reacts with tetrazine-modified molecules, enabling fast and selective ligation in biological systems. The PEG3 spacer improves solubility and reduces steric hindrance, enhancing reaction efficiency. The NHS ester reacts with primary amines on proteins, peptides, or amine-modified surfaces, allowing stable amide bond formation. Commonly applied in labeling, crosslinking, and functionalizing biomolecules for assays, imaging, drug delivery, and surface modification, especially where copper-free conditions are essential, such as live-cell labeling or in vivo applications.
Sizes / Availability / Pricing:
| Size | Availability | Price | Quantity |
|---|---|---|---|
| 0.100 | 10-20 days | Ft750,259.41 |
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TCO-PEG3-NHS ester
Used in bioconjugation to link biomolecules via strain-promoted alkyne-azide cycloaddition (SPAAC), a copper-free click chemistry reaction. The TCO (trans-cyclooctene) group rapidly reacts with tetrazine-modified molecules, enabling fast and selective ligation in biological systems. The PEG3 spacer improves solubility and reduces steric hindrance, enhancing reaction efficiency. The NHS ester reacts with primary amines on proteins, peptides, or amine-modified surfaces, allowing stable amide bond formation. Commonly applied in labeling, crosslinking, and functionalizing biomolecules for assays, imaging, drug delivery, and surface modification, especially where copper-free conditions are essential, such as live-cell labeling or in vivo applications.
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