1-((Trimethylsilyl)ethynyl)cyclopropane-1-carboxylic acid
98%
- Product Code: 243248
CAS:
1268810-07-6
| Molecular Weight: | 182.29 g./mol | Molecular Formula: | C₉H₁₄O₂Si |
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| EC Number: | MDL Number: | MFCD20660917 | |
| Melting Point: | Boiling Point: | ||
| Density: | Storage Condition: | Room temperature, inert gas |
Product Description:
Used as a key intermediate in organic synthesis, particularly in the preparation of pharmaceuticals and agrochemicals. Its alkyne functionality, protected by a trimethylsilyl group, allows for selective deprotection and coupling reactions, such as Sonogashira cross-coupling, enabling the construction of complex molecular architectures. The cyclopropane ring adds strain and rigidity, which can enhance binding selectivity in bioactive molecules. Commonly employed in medicinal chemistry for modifying lead compounds to improve metabolic stability and pharmacokinetic properties.
Sizes / Availability / Pricing:
| Size | Availability | Price | Quantity |
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| 0.100 | 10-20 days | €52.74 |
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| 0.250 | 10-20 days | €86.67 |
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| 1.000 | 10-20 days | €261.06 |
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| 5.000 | 10-20 days | €1,149.74 |
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1-((Trimethylsilyl)ethynyl)cyclopropane-1-carboxylic acid
Used as a key intermediate in organic synthesis, particularly in the preparation of pharmaceuticals and agrochemicals. Its alkyne functionality, protected by a trimethylsilyl group, allows for selective deprotection and coupling reactions, such as Sonogashira cross-coupling, enabling the construction of complex molecular architectures. The cyclopropane ring adds strain and rigidity, which can enhance binding selectivity in bioactive molecules. Commonly employed in medicinal chemistry for modifying lead compounds to improve metabolic stability and pharmacokinetic properties.
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