Lithium bis(trimethylsilyl)amide

1.0 M solution in THF, MKSeal

  • Product Code: 88704
  Alias:    Lithium bis(trimethylsilyl)amide; lithium hexamethyldisilazide, lithium bistrimethylsilylamide
  CAS:    4039-32-1
Molecular Weight: 167.33 g./mol Molecular Formula: C₆H₁₈LiNSi₂
EC Number: 223-725-6 MDL Number: MFCD00008261
Melting Point: 73°C Boiling Point: 55-56 °C
Density: 0.891 g/mL at 25 °C Storage Condition: 2~8 ℃
Product Description: Lithium bis(trimethylsilyl)amide is widely used as a strong, non-nucleophilic base in organic synthesis. It is particularly valuable in deprotonation reactions, where it facilitates the generation of carbanions from weakly acidic compounds. This makes it essential in the preparation of enolates, which are key intermediates in aldol reactions and other carbon-carbon bond-forming processes. Additionally, it is employed in the synthesis of organometallic compounds, where its ability to remove protons without interfering with the metal center is crucial. The chemical is also utilized in the production of specialty chemicals, including pharmaceuticals and agrochemicals, where precise control over reaction conditions is required. Its role in polymerization processes, particularly in anionic polymerization, further highlights its versatility in industrial applications.
Product Specification:
Test Specification
APPEARANCE PALE YELLOW TO AMBER LIQUID
Concentration 1.0 M
Infrared spectrum Conforms to Structure
NMR Conforms to Structure
Sizes / Availability / Pricing:
Size (g) Availability Price Quantity
100.000 10-20 days $78.43
+
-
500.000 10-20 days $214.63
+
-
1000.000 10-20 days $323.11
+
-
Lithium bis(trimethylsilyl)amide
Lithium bis(trimethylsilyl)amide is widely used as a strong, non-nucleophilic base in organic synthesis. It is particularly valuable in deprotonation reactions, where it facilitates the generation of carbanions from weakly acidic compounds. This makes it essential in the preparation of enolates, which are key intermediates in aldol reactions and other carbon-carbon bond-forming processes. Additionally, it is employed in the synthesis of organometallic compounds, where its ability to remove protons without interfering with the metal center is crucial. The chemical is also utilized in the production of specialty chemicals, including pharmaceuticals and agrochemicals, where precise control over reaction conditions is required. Its role in polymerization processes, particularly in anionic polymerization, further highlights its versatility in industrial applications.
Mechanism -
Appearance -
Longevity -
Strength -
Storage -
Shelf Life -
Allergen(s) -
Dosage (Range) -
Dosage (Per Day) -
Mix Method -
Heat Resistance -
Stable in pH range -
Solubility -
Product Types -
INCI -

Cart

No products

Subtotal: $0.00
$0.00 Total :

The availability date depends on real-time stock, and any changes after payment will be notified within 30 minutes
You can choose the delivery date on the next page