Lithium bis(trimethylsilyl)amide
24% in Tetrahydrofuran, MKSeal
- Product Code: 88726
Alias:
Lithium bis(trimethylsilyl)amide; lithium hexamethyldisilazide, lithium bistrimethylsilylamide
CAS:
4039-32-1
| Molecular Weight: | 167.33 g./mol | Molecular Formula: | C₆H₁₈LiNSi₂ |
|---|---|---|---|
| EC Number: | 223-725-6 | MDL Number: | MFCD00008261 |
| Melting Point: | -108°C | Boiling Point: | 65°C |
| Density: | 0.891 g/mL at 25 °C | Storage Condition: | 2~8℃ |
Product Description:
Lithium bis(trimethylsilyl)amide is widely used as a strong, non-nucleophilic base in organic synthesis. It is particularly effective in deprotonating weakly acidic compounds, such as carbonyl compounds, to generate enolates for use in aldol reactions and other carbon-carbon bond-forming processes. Its steric bulk prevents unwanted side reactions, making it a preferred choice in the synthesis of complex molecules, including pharmaceuticals and natural products. Additionally, it serves as a key reagent in the preparation of organometallic compounds, where it acts as a lithiating agent to introduce lithium into organic frameworks. Its ability to function in anhydrous conditions also makes it suitable for air- and moisture-sensitive reactions.
Product Specification:
| Test | Specification |
|---|---|
| APPEARANCE | PALE YELLOW TO AMBER LIQUID |
Sizes / Availability / Pricing:
| Size (g) | Availability | Price | Quantity |
|---|---|---|---|
| 100.000 | 10-20 days | ฿2,680.00 |
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| 5000.000 | 10-20 days | ฿26,800.00 |
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Lithium bis(trimethylsilyl)amide
Lithium bis(trimethylsilyl)amide is widely used as a strong, non-nucleophilic base in organic synthesis. It is particularly effective in deprotonating weakly acidic compounds, such as carbonyl compounds, to generate enolates for use in aldol reactions and other carbon-carbon bond-forming processes. Its steric bulk prevents unwanted side reactions, making it a preferred choice in the synthesis of complex molecules, including pharmaceuticals and natural products. Additionally, it serves as a key reagent in the preparation of organometallic compounds, where it acts as a lithiating agent to introduce lithium into organic frameworks. Its ability to function in anhydrous conditions also makes it suitable for air- and moisture-sensitive reactions.
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