Lithium bis(trimethylsilyl)amide
20% in Tetrahydrofuran, MKSeal
- Product Code: 88727
Alias:
Lithium bis(trimethylsilyl)amide; lithium hexamethyldisilazide, lithium bistrimethylsilylamide
CAS:
4039-32-1
| Molecular Weight: | 167.33 g./mol | Molecular Formula: | C₆H₁₈LiNSi₂ |
|---|---|---|---|
| EC Number: | 223-725-6 | MDL Number: | MFCD00008261 |
| Melting Point: | -108°C | Boiling Point: | 65°C |
| Density: | 0.891 g/mL at 25 °C | Storage Condition: | 2~8℃ |
Product Description:
Lithium bis(trimethylsilyl)amide is widely used as a strong, non-nucleophilic base in organic synthesis. It is particularly effective in deprotonating weakly acidic protons, making it valuable in the generation of carbanions for reactions such as aldol condensations, alkylations, and enolate formations. Its sterically hindered structure minimizes unwanted side reactions, ensuring high selectivity in complex transformations. Additionally, it serves as a key reagent in the synthesis of silicon-containing compounds and in the preparation of organometallic intermediates. Its role in polymerization processes, especially for anionic polymerization of certain monomers, is also noteworthy. Furthermore, it is utilized in the production of pharmaceuticals, agrochemicals, and advanced materials, highlighting its versatility in industrial and research applications.
Product Specification:
| Test | Specification |
|---|---|
| APPEARANCE | Clear or Slightly hazy, Pale yellow to Yellow to Brown Liquid |
| ASSAY | 18.0-22.0 |
| Infrared spectrum | Conforms to Structure |
| NMR | Conforms to Structure |
Sizes / Availability / Pricing:
| Size (g) | Availability | Price | Quantity |
|---|---|---|---|
| 500.000 | 10-20 days | $225.43 |
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| 5000.000 | 10-20 days | $1,173.63 |
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Lithium bis(trimethylsilyl)amide
Lithium bis(trimethylsilyl)amide is widely used as a strong, non-nucleophilic base in organic synthesis. It is particularly effective in deprotonating weakly acidic protons, making it valuable in the generation of carbanions for reactions such as aldol condensations, alkylations, and enolate formations. Its sterically hindered structure minimizes unwanted side reactions, ensuring high selectivity in complex transformations. Additionally, it serves as a key reagent in the synthesis of silicon-containing compounds and in the preparation of organometallic intermediates. Its role in polymerization processes, especially for anionic polymerization of certain monomers, is also noteworthy. Furthermore, it is utilized in the production of pharmaceuticals, agrochemicals, and advanced materials, highlighting its versatility in industrial and research applications.
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