Pep®-Sensyl is Acetyl Tetrapeptide-15 in water-soluble powder form, containing a Peptide concentration of 1500ppm.

Acetyl Tetrapeptide-15 in concentrations of 1350-1500ppm is often traded under the name Skinasensyl.

Acetyl tetrapeptide-15 is a peptide sequence derived from endomorphin-2 (Tyr-Pro-Phe-Phe-NH2), a human μ-opioid agonist. It has a skin desensitizing effect, thus reducing allergies and skin irritation. It is commonly used in products to reduce irritation, allergies and skin sensitivity.

Acetyl tetrapeptide-15 was developed with the aim of reducing skin hyperreactivity (decreased skin sensitivity) causing chronic inflammation and neuropathic pain through the activation of neurons in μ-opioid receptors.

The efficacy of this peptide has been demonstrated both in vitro and on real skin, with acetyl tetrapeptide-15 being tested for its ability to modulate CGRP release. CGRP is released following TRVP1 activation by Capsaisin.

The test was performed by incubating sensory neurons with acetyl tetrapeptide-15 (0.0003% and 0.001%), capsazepine (10 μM, a TRPV1 antagonist), or verapamil (100 μM, a calcium channel blocker) for 6 h and then exposing them to KCl and capsaicin. It was found that 0.001% acetyl tetrapeptide-15 significantly reduced CGRP release when neurons were exposed to both capsaicin and KCl, more effectively than 10 μM capsazepine.

A blinded clinical study demonstrated the ability of acetyl tetrapeptide-15 to reduce skin sensitivity following capsaicin exposure in 20 subjects. The protocol began by applying increasing concentrations of capsaicin solution intranasally to determine the concentration that produced discomfort. Then, a 0.0015% solution containing acetyl tetrapeptide-15 was applied twice daily for four days, and the application was repeated to increase the capsaicin concentration. Overall, there was a significant increase in the capsaicin threshold, demonstrating its efficacy.

Various research studies have confirmed that Acetyl tetrapeptide-15 can help reduce skin sensitivity, making it suitable for use in formulas that require reducing skin irritation.

Usage: For products that reduce skin irritation.

Mixing method: Mix in the final step. Avoid heat. Can be dissolved in water.

Usage rate: 0.3-1%

Product appearance: white powder

Solubility: Can be dissolved in water.

Storage: For long-term storage, keep refrigerated. Avoid exposure to sunlight and heat. Seal the lid tightly.

INCI Name : Mannitol (and) Sodium Citrate (and) Acetyl Tetrapeptide-15