Ceramide 3 (Ceramide NP, N-stearoyl-phytosphingosine type) - High purity powder ceramide (>90%) equivalent to Croda Y3S or Evonik Ceramide III. Superior barrier reinforcement.

Ceramide 3 (also known as Ceramide NP, N-stearoyl-phytosphingosine type)™ is a high-purity powder form ceramide with over 90% purity, structurally similar to ceramides found naturally in human skin.

This specific variant contains N-stearoyl-phytosphingosine as the primary fatty acid chain, equivalent to commercial products like Croda Y3S or Evonik Ceramide III. The stearic acid chain provides excellent structural compatibility with the skin's lipid bilayers, making it particularly effective for barrier restoration.

N-stearoyl-phytosphingosine variant offers superior barrier reinforcement due to its saturated fatty acid chain, providing long-lasting moisturization and protection. It works by integrating into the skin's lipid matrix, helping to restore the natural barrier function that is essential for healthy skin.

Clinical Research & Evidence:

Reinforce the skin barrier & cut water loss. Randomized and controlled clinical trials of ceramide-containing moisturizers show significant improvements in transepidermal water loss (TEWL) and hydration versus comparators, with parallel improvements in eczema severity scores. Most formulas in these studies include Ceramide NP among other skin-identical lipids.

Improve signs/symptoms of eczema & dermatitis. In adults with eczema, a ceramide-dominant regimen improved barrier function and symptoms; a separate RCT in mild–moderate atopic dermatitis found a ceramide cream (vs. hydrocortisone or standard emollient) improved hydration and clinical scores.

Direct relevance of NP subclass to barrier quality. Observational work links a higher Ceramide NP : NS ratio in the stratum corneum with healthier barrier properties; modeling data also show that changing the NS:NP ratio alters lipid packing and permeability—supporting NP's structural role in barrier integrity.

Mechanistic fit: fills lipid "mortar." Reviews of phytosphingosine-based ceramides (including CER[NP]) describe how they assemble with cholesterol and free fatty acids into lamellar structures that maintain cohesion, resilience, and water retention in the outer skin layer.

Usage: Suitable for all skincare products including creams, lotions, serums, anti-aging formulations, and barrier repair treatments. Excellent for sensitive, dry, and compromised skin products.

How to mix:

- Pre-disperse in oil phase at 70-80°C until fully dissolved

- Can be combined with other ceramides, cholesterol, and fatty acids for optimal barrier repair

- Add to formulation during oil phase incorporation

Usage rate: 0.1-2.0%

Product Description: White to light yellow powder with purity greater than 90%

Solubility: Soluble in oils and organic solvents at elevated temperature (70-80°C), insoluble in water

Storage: Store in a cool, dry place away from light. Keep container tightly closed. Shelf life 2 years.

INCI Name: Ceramide NP