precursor of nicotinamide adenine dinucleotide (NAD+), which plays a crucial role in various cellular processes, including energy metabolism, DNA repair, and regulation of oxidative stress

Nicotinamide mononucleotide (NMN) is a precursor of nicotinamide adenine dinucleotide (NAD+), which plays a crucial role in various cellular processes, including energy metabolism, DNA repair, and regulation of oxidative stress. Recent research has explored the potential topical benefits of NMN, particularly in the context of skin health and aging.

Skin Inflammation and Eczema

A study by researchers from Wuhan University, China, demonstrated that topical application of NMN could alleviate symptoms of eczema (atopic dermatitis) in mice[3]. The findings suggest that NMN prevents severe skin damage, reduces harmful reactive oxygen species (ROS), and improves skin barrier function by increasing antioxidant levels and proteins involved in skin barrier maintenance.

Skin Aging and Oxidative Stress

Several studies have indicated that NMN can protect skin cells from oxidative stress caused by factors such as ultraviolet radiation, air pollution, and particulate matter[3]. By limiting ROS and oxidative stress, which are underlying causes of skin aging, NMN may potentially slow down or prevent accelerated skin aging.

NAD+ Levels and Inflammation

NMN supplementation has been shown to increase NAD+ levels, which can modulate inflammatory responses and oxidative stress[4][5]. By boosting NAD+ levels, NMN may help alleviate inflammatory conditions in the skin and other tissues.

Clinical Studies

While most research on the topical benefits of NMN has been conducted in animal models, a recent randomized, multicenter, double-blind, placebo-controlled clinical trial evaluated the safety and efficacy of oral NMN supplementation in healthy middle-aged adults[2]. The study found that NMN supplementation increased blood NAD+ concentrations and improved physical performance, with the highest efficacy observed at a dose of 600 mg daily. However, more clinical studies are needed to specifically investigate the topical application and effects of NMN on skin health and aging.

In summary, current research suggests that topical application of NMN may have potential benefits for skin health, including reducing inflammation, alleviating eczema symptoms, and protecting against oxidative stress and skin aging[3][4][5]. However, further clinical studies are warranted to establish the safety and efficacy of topical NMN in humans.

Citations:
[1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9039735/
[2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9735188/
[3] https://www.nmn.com/news/topical-nmn-relieves-inflammatory-skin-disease
[4] https://www.sciencedirect.com/science/article/pii/S2161831323013595
[5] https://www.mdpi.com/2076-3921/13/2/186

Use: Use in anti-aging formulation.

How to mix: Mixed with the water phase

Utilization rate: 0.2-2.0%

Product characteristics: White powder

Solubility: can dissolve in water

Storage: Can be stored in the refrigerator (2-10 degrees), avoiding sunlight or heat. The product has a minimum shelf life of 2 years.

INCI Name : Nicotinamide mononucleotide