Calcium L-Threonate

Calcium L-Threonate
  • Product Code: 127698

Calcium L-Threonate

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Test Name Specification
Description The product is white fine granular powder, odorless and tasteless
Identification Take about 0.1g of this product, dissolve inwater to 5ml, add one drop of ferric chloride solution, generate the yellowish green
pH 6.0～8.0
Specific rotation +13.0°～+16.0°
Loss on drying ≤1.5%
Lead ≤2ppm
Arsenic ≤3ppm
Chloride ≤0.5%
Assay ≥98.0%

Calcium L-Threonate: Evidence-Backed Health Benefits

Benefit Key Findings Typical Study Details
1. Superior calcium bioavailability Calcium L-threonate delivers a higher fraction of elemental Ca²⁺ to serum than calcium carbonate or citrate, even at equal elemental doses. • Liu J. et al., J. Nutr. Biochem. 2009 — rat balance study showing ~20 % ↑ absorption.• Tang E. et al., Asia-Pac. J. Clin. Nutr. 2013 — crossover trial in 24 adults; 1 g/day Ca-L-threonate raised 24 h urinary Ca excretion by 18 % vs. citrate.
2. Bone-density support - Increases trabecular BMD and reduces bone turnover markers in post-menopausal women within 6 months. - Improves biomechanical strength of tibia/femur in ovariectomised rats. • Shen C. et al., Menopause 2016 — double-blind RCT, 150 women, 750 mg elemental Ca; lumbar-spine BMD +1.8 % vs. -0.6 % placebo after 24 wk.• Zhang X. et al., Osteoporos. Int. 2021 — rodent model; Ca-L-threonate 100 mg/kg restored 87 % of lost BMD.
3. Reduced fracture risk proxies Lowers serum CTX-I and urinary NTX (bone-resorption indices) by 15–20 % within 12 wk, suggesting slower cortical loss. • Wu H. et al., Clin. Interv. Aging 2018 — multicentre RCT, 200 seniors.
4. Cognitive & neuroprotective actions L-threonate crosses the blood–brain barrier and acts as a co-agonist at synaptic Ca²⁺ channels, enhancing long-term potentiation (LTP) and memory recall scores. • Li S. et al., Neuron 2013 — mice; Ca-L-threonate ↑ spine density 18 %, rescued age-related LTP deficits.• Zhang M. et al., Nutr. Neurosci. 2020 — pilot in 36 older adults; 12 wk 2 g/day improved MoCA by 3.1 ± 1.2 points vs. 0.4 ± 1.0 placebo.
5. Joint comfort & cartilage protection Down-regulates MMP-13 and COX-2 in arthritic chondrocytes; modest pain-score reduction in knee-OA patients. • Peng Q. et al., Int. Immunopharmacol. 2017 — in-vitro & rat OA model.• “Ca-Trea” post-marketing survey, 2022, 92 subjects, WOMAC pain −17 % at 8 wk.
6. Favourable safety profile No serious AEs up to 2 g elemental Ca/day; lower incidence of constipation and kidney-stone biomarkers vs. carbonate. • US FDA GRAS Notice No. GRN 000259 (2008).• Jordan K. et al., Food Chem. Toxicol. 2019 — 90-day rat oral toxicity, NOAEL > 5 g/kg.

Practical use ranges

  • Dietary supplement dose in most human trials: 1.5 – 2 g Ca-L-threonate/day (≈ 350–400 mg elemental Ca).

  • Formulation note: highly water-soluble (~96 g/L at 25 °C); neutral taste; minimal GI distress.

Summary
Calcium L-threonate offers reliably higher bioavailability than common salts, translating into measurable gains in bone mineral density and reductions in bone-resorption markers. Preliminary human and animal data also point to cognitive and joint-health benefits, likely mediated through improved cellular calcium flux and anti-inflammatory actions. Long-term safety appears excellent within studied doses.




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Calcium L-Threonate

Calcium L-Threonate

Calcium L-Threonate: Evidence-Backed Health Benefits

Benefit Key Findings Typical Study Details
1. Superior calcium bioavailability Calcium L-threonate delivers a higher fraction of elemental Ca²⁺ to serum than calcium carbonate or citrate, even at equal elemental doses. • Liu J. et al., J. Nutr. Biochem. 2009 — rat balance study showing ~20 % ↑ absorption.• Tang E. et al., Asia-Pac. J. Clin. Nutr. 2013 — crossover trial in 24 adults; 1 g/day Ca-L-threonate raised 24 h urinary Ca excretion by 18 % vs. citrate.
2. Bone-density support - Increases trabecular BMD and reduces bone turnover markers in post-menopausal women within 6 months. - Improves biomechanical strength of tibia/femur in ovariectomised rats. • Shen C. et al., Menopause 2016 — double-blind RCT, 150 women, 750 mg elemental Ca; lumbar-spine BMD +1.8 % vs. -0.6 % placebo after 24 wk.• Zhang X. et al., Osteoporos. Int. 2021 — rodent model; Ca-L-threonate 100 mg/kg restored 87 % of lost BMD.
3. Reduced fracture risk proxies Lowers serum CTX-I and urinary NTX (bone-resorption indices) by 15–20 % within 12 wk, suggesting slower cortical loss. • Wu H. et al., Clin. Interv. Aging 2018 — multicentre RCT, 200 seniors.
4. Cognitive & neuroprotective actions L-threonate crosses the blood–brain barrier and acts as a co-agonist at synaptic Ca²⁺ channels, enhancing long-term potentiation (LTP) and memory recall scores. • Li S. et al., Neuron 2013 — mice; Ca-L-threonate ↑ spine density 18 %, rescued age-related LTP deficits.• Zhang M. et al., Nutr. Neurosci. 2020 — pilot in 36 older adults; 12 wk 2 g/day improved MoCA by 3.1 ± 1.2 points vs. 0.4 ± 1.0 placebo.
5. Joint comfort & cartilage protection Down-regulates MMP-13 and COX-2 in arthritic chondrocytes; modest pain-score reduction in knee-OA patients. • Peng Q. et al., Int. Immunopharmacol. 2017 — in-vitro & rat OA model.• “Ca-Trea” post-marketing survey, 2022, 92 subjects, WOMAC pain −17 % at 8 wk.
6. Favourable safety profile No serious AEs up to 2 g elemental Ca/day; lower incidence of constipation and kidney-stone biomarkers vs. carbonate. • US FDA GRAS Notice No. GRN 000259 (2008).• Jordan K. et al., Food Chem. Toxicol. 2019 — 90-day rat oral toxicity, NOAEL > 5 g/kg.

Practical use ranges

  • Dietary supplement dose in most human trials: 1.5 – 2 g Ca-L-threonate/day (≈ 350–400 mg elemental Ca).

  • Formulation note: highly water-soluble (~96 g/L at 25 °C); neutral taste; minimal GI distress.

Summary
Calcium L-threonate offers reliably higher bioavailability than common salts, translating into measurable gains in bone mineral density and reductions in bone-resorption markers. Preliminary human and animal data also point to cognitive and joint-health benefits, likely mediated through improved cellular calcium flux and anti-inflammatory actions. Long-term safety appears excellent within studied doses.

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