Tetrahydroxypropyl Ethylenediamine (THPE, e.q. Neutrol TE)
Tetrahydroxypropyl Ethylenediamine (THPE)
INCI: Tetrahydroxypropyl Ethylenediamine • CAS 102-60-3
A highly water-soluble tetra-amine obtained by reacting ethylenediamine with propylene oxide. In the EU CosIng database it is classified primarily as a chelating agent with no special use restrictions. European Commission
Why formulators use it
| Technical role |
How it helps |
Typical levels* |
Key references |
| Chelator / metal-ion scavenger |
Binds trace Fe³⁺ / Cu²⁺ that catalyse oxidation, stabilising colours, fragrances and actives. |
0.1 – 0.5 % |
CosIng, INCIDecoder (European Commission, INCIDecoder) |
| pH-buffer / neutraliser |
Strong base (pKa ≈ 9); efficiently neutralises carbomer or acrylic rheology modifiers, even in hydro-alcoholic gels where TEA fails. |
0.2 – 1 % |
BASF “Neutrol TE” tech sheet (Ross Organic) |
| Instant skin-tightening active |
Induces reversible cytoskeletal contraction in superficial keratinocytes → visible “lifting” and wrinkle smoothing within ~45 min. |
1.5 – 2.5 % (study cream) |
PubMed 21968659 (PubMed), JDD study (JDD Online) |
| Deodorant deodoriser co-factor |
Part of Zinc-ricinoleate/Sarcosinate/THPE complex that traps malodour volatiles. |
1 – 3 % (in concentrate) |
MakingCosmetics DeoConcentrate FS (MakingCosmetics) |
*Levels refer to the finished formula unless noted.
Performance as an anti-ageing active
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Mechanism: THPE triggers a re-organisation of F-actin in the outermost living keratinocytes, shrinking their apical surface. This flattens micro-relief and increases light reflection (“instant radiance”).
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Clinical data: A cream containing 2.5 % THPE delivered a 22.9 % smoother surface and 1.8 mm measurable lifting after 8 weeks of twice-daily use, with effects already visible at 45 minutes. (JDD Online)
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Synergy: Formulas combining THPE with humectants (e.g., glycerin) and phyto-extracts (e.g., Ononis spinosa) showed additional long-term firmness gains. (SCIRP)
Formulation guidelines
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Dissolution & addition
- Readily dissolves in water; add to the aqueous phase at ≤ 40 °C or during cool-down.
- When used as a neutraliser, add slowly to the carbomer dispersion under moderate mixing until target pH/viscosity is reached.
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Alcohol compatibility
- Remains effective in gels containing up to 60 % ethanol, making it ideal for clear sanitiser or toner gels where TEA can precipitate salts. (PMC)
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pH window
- Stable from pH 4 – 10. For anti-ageing “tightening” claims, keep final pH 5.0 – 6.5 to match clinical studies.
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Interactions
- Strongly chelates metals—use plastic or 316L stainless equipment.
- Avoid simultaneous addition with divalent metal actives (Zn, Mg) unless chelation is desired.
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Preservation & stability
- Does not quench common preservatives.
- Compatible with glycols, anionic, non-ionic, and amphoteric surfactants.
Usage: For all types of products By acting as a Chelating Agent
Mixing method: Mix in water (water-phase), avoid heat over 80 degrees.
Usage rate: 0.1-2%
Product characteristics: clear liquid
Solubility: can dissolve in water
Storage: Can be stored in a cool place. Close the bottle cap tightly. Then completely protected from sunlight, air or heat. The product has a minimum shelf life of 2 years.
INCI Name : Tetrahydroxypropyl Ethylenediamine
