Squalene (Water Soluble, 24% Squalene)

Squalene (Water Soluble, 24% Squalene)
Cosmetics Code: 171053

Lipid that mimics human sebum, fills inter-corneocyte lipid spaces and lowers transepidermal water loss

฿234.78
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Key topical benefits of squalene (naturally occurring triterpene, not the hydrogenated “squalane”)

Benefit Mechanistic highlights Typical effective levels* Supporting evidence
Powerful emollient & barrier-reinforcer • Lipid that mimics human sebum, fills inter-corneocyte lipid spaces and lowers transepidermal water loss (TEWL).
• Restores lipid matrix after irritant damage (e.g., SLS).		 0.5 – 5 % in lotions/serums; 10 – 20 % in cleansing oils Okuda et al. reversed SLS-induced TEWL rise in human & rat skin with topical 2 % squalene pmc.ncbi.nlm.nih.gov. 2024 review summarises barrier-support data across 20 in-vitro/clinical papers pmc.ncbi.nlm.nih.gov
Antioxidant & photoprotective • Efficient singlet-oxygen quencher (k ≈ 1 × 108 M⁻¹ s⁻¹), intercepting UV-induced radicals before they hit membrane lipids or DNA.
• Limits lipid-peroxide cascade that leads to photo-ageing.		 0.5 – 2 % combined with UV filters or vitamins C/E UVA generates squalene monohydroperoxides that serve as oxidative-stress markers; intact squalene mitigates their formation when supplied exogenously pubmed.ncbi.nlm.nih.govpmc.ncbi.nlm.nih.gov
Anti-inflammatory & soothing • Down-regulates NF-κB and COX-2; decreases IL-6 / PGE₂ in keratinocytes and fibroblasts.
• Peroxidised squalene is pro-inflammatory—emphasises need for antioxidant pairing/formulation control.		 0.5 – 1 % in leave-on formulations Cell-culture work shows native squalene cuts ROS and inflammatory cytokines, while its peroxide triggers the opposite response sciencedirect.compmc.ncbi.nlm.nih.gov
Wound-healing & collagen support • Accelerates fibroblast migration (scratch assay) and restores collagen biosynthesis suppressed by UVA.
• Promotes macrophage-mediated tissue repair in vivo.		 0.01 – 0.1 % for cell-culture benefits; 0.5 – 3 % in gels/creams Human-dermal-fibroblast study: 0.005–0.015 % squalene increased wound closure and rescued collagen expression after UVA mdpi.com
Complementary penetration enhancer / delivery lipid • 30-carbon chain gives low viscosity and high spreadability, improving solubilisation of lipophilic actives without stinging.
• Favours nano-emulsion and NLC systems for actives such as retinoids or bakuchiol.		 2 – 15 % in oil phases Broad cosmetic-dermatology review notes its frequent use in nanostructured lipids for enhanced percutaneous delivery pmc.ncbi.nlm.nih.gov

*Formulation ranges gathered from peer-reviewed papers and INCI listings; always verify with stability and safety testing for your specific product.


Formulation notes

  • Oxidation control: Squalene’s six double bonds make it UV-sensitive; combine with UV-stable antioxidants (α-tocopherol, rosemary extract) and package in air-tight, light-protected containers.

  • Squalene vs. squalane: Squalane is the hydrogenated, oxidation-resistant cousin; when stability is paramount (e.g., clear serums), swap part or all of the squalene for squalane and keep the sensory/moisturising profile.

  • Ideal partners: Ceramide NP (barrier synergy), niacinamide (anti-inflammatory + lipid-boost), and low-HLB emulsifiers that minimise peroxidation.



Usage: Use in any recipe

Mixing method: Mix together with water.

Usage rate: 1-20%

Product characteristics: Clear, colorless-light yellow liquid

Solubility: Can dissolve in water.

Storage: Can be stored at room temperature But close the bottle cap tightly. Then completely protected from sunlight or heat. The product has a minimum shelf life of 2 years.

 

INCI Name: Squalene


  • Room (25-40C)
  • 24 Months from manufacturing or testing date.
  • 0.10% - 20.00%
  • 20.00%
  • Add into water phase. Heat tolerant.
  • Avoid heat above 80C
  • 0.00 - 0.00
  • Soluble in Oil, Dispersible in water, Dispersible in cream or gel base
  • Cream, Lotion, Serum
  • -
Test Name Specification
Characteristics Transparent viscous liquid
Content (capric acid) 23.0-25.0%
Arsenic (As) ≤2ppm
Lead (Pb) ≤10ppm
Cadmium (Cd) ≤5ppm
Mercury (Hg) ≤1ppm
Aerobic bacterial count ≤100CFU/mL
Yeast and mold count ≤10CFU/mL
Staphylococcus aureus, Pseudomonas aeruginosa, heat-resistant E. coli Not detected

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Squalene (Water Soluble, 24% Squalene)

Lipid that mimics human sebum, fills inter-corneocyte lipid spaces and lowers transepidermal water loss

Key topical benefits of squalene (naturally occurring triterpene, not the hydrogenated “squalane”)

Benefit Mechanistic highlights Typical effective levels* Supporting evidence
Powerful emollient & barrier-reinforcer • Lipid that mimics human sebum, fills inter-corneocyte lipid spaces and lowers transepidermal water loss (TEWL).
• Restores lipid matrix after irritant damage (e.g., SLS).		 0.5 – 5 % in lotions/serums; 10 – 20 % in cleansing oils Okuda et al. reversed SLS-induced TEWL rise in human & rat skin with topical 2 % squalene pmc.ncbi.nlm.nih.gov. 2024 review summarises barrier-support data across 20 in-vitro/clinical papers pmc.ncbi.nlm.nih.gov
Antioxidant & photoprotective • Efficient singlet-oxygen quencher (k ≈ 1 × 108 M⁻¹ s⁻¹), intercepting UV-induced radicals before they hit membrane lipids or DNA.
• Limits lipid-peroxide cascade that leads to photo-ageing.		 0.5 – 2 % combined with UV filters or vitamins C/E UVA generates squalene monohydroperoxides that serve as oxidative-stress markers; intact squalene mitigates their formation when supplied exogenously pubmed.ncbi.nlm.nih.govpmc.ncbi.nlm.nih.gov
Anti-inflammatory & soothing • Down-regulates NF-κB and COX-2; decreases IL-6 / PGE₂ in keratinocytes and fibroblasts.
• Peroxidised squalene is pro-inflammatory—emphasises need for antioxidant pairing/formulation control.		 0.5 – 1 % in leave-on formulations Cell-culture work shows native squalene cuts ROS and inflammatory cytokines, while its peroxide triggers the opposite response sciencedirect.compmc.ncbi.nlm.nih.gov
Wound-healing & collagen support • Accelerates fibroblast migration (scratch assay) and restores collagen biosynthesis suppressed by UVA.
• Promotes macrophage-mediated tissue repair in vivo.		 0.01 – 0.1 % for cell-culture benefits; 0.5 – 3 % in gels/creams Human-dermal-fibroblast study: 0.005–0.015 % squalene increased wound closure and rescued collagen expression after UVA mdpi.com
Complementary penetration enhancer / delivery lipid • 30-carbon chain gives low viscosity and high spreadability, improving solubilisation of lipophilic actives without stinging.
• Favours nano-emulsion and NLC systems for actives such as retinoids or bakuchiol.		 2 – 15 % in oil phases Broad cosmetic-dermatology review notes its frequent use in nanostructured lipids for enhanced percutaneous delivery pmc.ncbi.nlm.nih.gov

*Formulation ranges gathered from peer-reviewed papers and INCI listings; always verify with stability and safety testing for your specific product.


Formulation notes



Usage: Use in any recipe

Mixing method: Mix together with water.

Usage rate: 1-20%

Product characteristics: Clear, colorless-light yellow liquid

Solubility: Can dissolve in water.

Storage: Can be stored at room temperature But close the bottle cap tightly. Then completely protected from sunlight or heat. The product has a minimum shelf life of 2 years.

 

INCI Name: Squalene

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