Heptadecanoic Acid (C17:0, 98%)
Cosmetics
Code: 233205
Pre-incubating macrophages with C 17:0 suppresses Listeria monocytogenes replication and boosts pathogen-clearing responses.
Topical benefits of Heptadecanoic Acid (C 17:0)
| Benefit cluster | Key research insights | Practical formulation take-aways |
|---|---|---|
| Antimicrobial & skin-immune support | Pre-incubating macrophages with C 17:0 suppresses Listeria monocytogenes replication and boosts pathogen-clearing responses. | Helps curb bacterial/yeast overgrowth that triggers rashes, acne, malodour or secondary infection—useful in deodorants, face washes, scalp or wound-dressing products. |
| Anti-inflammatory (“inflamm-aging” control) | The same studies show C 17:0 modulates Toll-like receptors, up-regulates anti-inflammatory cytokines and lowers ROS in activated macrophages. | Can soothe redness or itching and slow oxidative stress-driven ageing—especially valuable in post-sun or pollution-protection formulas. |
| Barrier reinforcement | Odd-chain fatty acids (C15–C23) make up ≈30 % of stratum-corneum free fatty acids and help pack lipid lamellae more tightly. | Adding 0.2–1 % C 17:0 in the oil phase can restore the native fatty-acid profile, reduce TEWL and improve suppleness. |
| Mitochondrial & antioxidant support | Reviews on odd-chain fatty acids note that C 17:0 feeds the citric-acid cycle and lowers mitochondrial ROS under nutrient stress. | Provides a stable antioxidant “assist” in repair serums without the oxidation liability of unsaturated oils. |
| High-stability, cushiony emollient | Melting point ≈ 61 °C; saturated, odourless white solid. | Creates a soft, “cushion” film like stearic acid but is slower to turn grainy and far less prone to rancidity—ideal for day/night creams or protective balms. |
Formulation notes
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INCI / CAS: Heptadecanoic Acid (CAS 506-12-7). No specific restrictions in EU, US or ASEAN cosmetic lists.
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Recommended loadings: 0.1–1 % w/w in leave-on products; up to ~2 % in rinse-off formulas.
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Processing tips
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Melt C 17:0 together with the main emollient (e.g. squalane, caprylic/capric triglyceride) at ≥ 70 °C until clear.
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Cool under moderate shear; very rapid cooling or weak agitation may leave coarse crystalline “bloom.”
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For clear systems, pre-solubilise in 0.5–1 % PEG-7 glyceryl cocoate or another non-ionic surfactant before adding to the water phase.
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A small dose of mixed tocopherols (0.05–0.1 %) protects colour and keeps the base bright over shelf life.
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Compatibility: Works well with niacinamide, synthetic ceramides, phenoxyethanol/chlorphenesin preservative blends, and most common UV filters.
Usage: For any skin care product
Mixing method: dissolved in oil
Usage rate: 1-20%
Product characteristics: : White flake powder
Solubility: Can dissolve in oil
Storage: If you want to keep it for the long term Store at room temperature. At least 24 months old
INCI Name : Heptadecanoic acid
- Room (25-40C)
- 24 Months from manufacturing or testing date.
- 0.10% - 20.00%
- 0.00%
- Add into oil phase. Heat tolerant.
- Heat Tolerant
- 3.50 - 9.00
- Soluble in Oil, Dispersible in cream or gel base, Dispersible in powder, Soluble in DMSO (Dimethyl Sulfoxide)
- Cream, Lotion, Serum
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| Test Name | Specification |
|---|---|
| Appearance | White to off-white fine powder |
| Odor | Characteristic |
| Taste | Characteristic |
| Bulk Density | 30-70g/100mL |
| Particle Size | NLT 95% through 80 mesh |
| Assay | >98.0% |
| Identification | Correspond to the RS |
| Loss on drying | ≤5.0% |
| Ash | ≤5.0% |
| Total Heavy Metals | ≤10 ppm |
| Lead (Pb) | ≤0.5 ppm |
| Arsenic (As) | ≤2.0 ppm |
| Cadmium (Cd) | ≤0.1 ppm |
| Mercury (Hg) | ≤0.1 ppm |
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