Accelerates epidermal turnover & brightens skin, Clinically proven against hyperpigmentation

Adenosine Phosphate Disodium (AMP-Na) (adenosine 5-monophosphate sodium salt)

Accelerates epidermal turnover & brightens skin

In the clinical study “Improvement of hyperpigmentation based on accelerated epidermal turnover: Clinical effects of disodium adenosine monophosphate in patients with melasma” by Kawashima M., Mizuno A. and Murata Y. (Jpn J Clin Dermatol. 2008;62:250–257), a 3% disodium adenosine phosphate cream was applied twice daily for 12 weeks. Treated subjects showed a significant rise in keratinocyte ATP metabolism, which accelerated epidermal renewal and enhanced melanin excretion, leading to visibly brighter skin in melasma lesions.

Clinically proven against hyperpigmentation

The same quasi-drug trial by Kawashima et al. reported a 35% reduction in Melasma Area and Severity Index (MASI) scores and noticeable lightening of solar lentigo after 12 weeks of twice-daily application of the 3% formulation, confirming its efficacy in reversing hyperpigmented conditions (Jpn J Clin Dermatol. 2008;62:250–257).

Stimulates collagen synthesis & reduces wrinkles

Perez-Aso M., Fernandez P., Mediero A., Chan E.S. and Cronstein B.N. demonstrated in “Adenosine 2A receptor promotes collagen production by human fibroblasts via pathways involving cyclic AMP and AKT but independent of Smad2/3” (FASEB J. 2014 Feb;28(2):802–812) that selective A₂A receptor activation with CGS21680 in primary human dermal fibroblasts increased collagen I and III synthesis through a cAMP/AKT-dependent, Smad2/3-independent pathway, correlating with improved skin firmness and reduced wrinkle depth in subsequent clinical observations.

Enhances skin smoothness & hydration

In “Adenosine-loaded dissolving microneedle patches to improve skin wrinkles, dermal density, elasticity and hydration” by Kang G., Baek S., Yang H., Kim S. and Jung H. (Int J Cosmet Sci. 2018 Apr;40(2):199–206), subjects applied either an adenosine cream twice daily or a dissolving microneedle patch once every three days for 8 weeks. Both treatments significantly improved skin texture, but the microneedle patches delivered superior increases in hydration and smoothness, as measured by corneometry and dermal density analysis.

Soothes & supports wound healing

Montesinos M.C., Gadangi P., Longaker M., Sung J., Levine J., Nilsen D., Reibman J., Li M., Jiang C.K., Hirschhorn R., Recht P.A., Ostad E. and Cronstein B.N. showed in “Wound healing is accelerated by agonists of adenosine A₂ (Gαs-linked) receptors” (J Exp Med. 1997 Sep 1;186(9):1615–1620) that topical activation of A₂A receptors enhanced endothelial cell proliferation, angiogenesis, and granulation tissue formation in both normal and diabetic wound models, confirming adenosine’s anti-inflammatory and reparative benefits.

Usage: For exfoliating products.

Mixing method: Mix in water (water-phase), avoid heat exceeding 40 degrees.

Usage rate: 1-3%

Product characteristics: White powder.

Solubility: Soluble in water.

Storage: Can be stored in a cool place (refrigerated recommended). Close the bottle tightly and keep away from sunlight, air or heat. The product has a shelf life of at least 2 years.

INCI Name: Adenosine Phosphate Disodium