Dimethyl Isosorbide (DMI)

Dimethyl Isosorbide (DMI)


Dimethyl Isosorbide or Isosorbide dimethyl ether, or DMI for short, is a solvent that has the effect of bringing (penetration enhancer) ingredients to the skin well.

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Expiration: 01/2025 (Lot: WP816M)

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Dimethyl Isosorbide or Isosorbide dimethyl ether, or DMI for short, is a solvent that has the effect of bringing (penetration enhancer) ingredients to the skin well.


DMI types that the company sells With the highest purity Without lower than 99.0%


DMI is suitable for conveying water-soluble ingredients.


DMI limitations: It has an ether-like scent when used in formulations. perfume To help cover the smell or use Odor-Kill 1% to help absorb the smell of DMI in the formula.


Example of Active Ingredients with Clinical Trial when used in conjunction with DMI, resulting in higher efficacy. Or reduce skin irritation:

1. Dihydroxyacetone It can provide better self-tanning performance.

2. Salicylic Acid Can reduce irritation

3. Lactic Acid Can reduce irritation

4. Vitamin C (L-Ascorbic Acid) Can provide better performance

5. Vitamin E   Can provide better performance

6. Hyaluronic Acid   Can provide better performance

7. Kojic Acid   Can provide better performance


Examples of applications in different products:

- Neutrogena chose DMI to help bring sunless tan ingredients, Dihydroxyacetone in the formula. Neutrogena   Micromist airbrush sunless tan

- The Ordinary selects DMI to help dissolve Salicylic Acid in The Ordinary Salicylic Acid 2% Solution formula.

- The Ordinary chooses to use DMI to carry various ingredients in the formula. The Ordinary Niacinamide 10% + Zinc 1% and The Ordinary Ascorbyl Glucoside Solution 12%.

- Dr. Murad uses DMI to bring various ingredients in the formula Murad White Brilliance Luminous Essence.


The company sells ingredients that help lead (Penetration Enhancer) as follows:

1. Laurocapram (Water-Soluble) Soluble in water, suitable for conveying dissolved ingredients Synthetic It does not have a smell or has a mild smell.

2. Laurocapram (Oil-Soluble) Soluble in oil Suitable for conveying oil-soluble ingredients Is a synthetic substance with a mild smell

3. Phospholipid Suitable for conveying Both the water-soluble and oil-soluble ingredients are formed from natural modifications to the structure of Soy Lecithin, but through a chemical process, they have a good skin feel. Can help add moisture to the skin.

4. 1,2-Hexanediol Can be used to help increase efficiency in conveying In combination with 1,2,3 with other benefits as well (preservative) provides the formula, dissolves some ingredients in the formula, is a humectant, helps retain moisture in the skin.

5. Ethoxydiglycol   Can be used to help increase efficiency in conveying It is used in conjunction with 1,2,3. It has other benefits as well, such as helping to dissolve certain ingredients in the formulation. (Currently, the FDA has a limited usage rate. Please check the latest rules. Before being used in formulas)

6. Reservoir-Tech Not a direct carrier Rather, it is a film-forming agent on the skin to help retain active ingredients in the formula by gradually releasing active substances into the skin, which can reduce irritation. For some ingredients such as AHA, BHA can not be used with 1,2,3.

7. Dimethyl Isosorbide (DMI) Carrier with a long history of use Both in terms of safety And efficiency But it is popular only in high-priced branded products due to the higher price of DMI. Other types of conductors


Usage: Mixed in any product

Mixing method: Mix in several stages. Can withstand heat up to 80 degrees.

Rate of use: 1-10% (Recommended 3% for use with ingredients, choose 1-10% for dissolving ingredients Using at a rate sufficient to dissolve)

Product characteristics: Colorless or light yellow clear liquid There is an ether characteristic smell.

Solubility: Soluble in water, various glycol, alcohol, polysorbate (tween), mineral oil, lanolin, silicone oil (dimethicone).

Storage: Can be stored in a cool 2-6 degrees, but close the bottle tightly. And sealed from direct sunlight or heat, the product is at least 2 years old


INCI Name : A. Dimethyl Isosorbide

Purity 99.0% Minimum


Examples of products used Dimethyl Isosorbide


The ordinary arginine solution 10%
The Ordinary Caffeine Solution 5% + EGCG
The Ordinary Granactive Retinoid 2% in Squalane
The Ordinary Amino Acids + B5
The Ordinary Niacinamide 10% + Zinc 1%
The Ordinary Azelaic Acid Suspension 10%
LA ROCHE-POSAY Effaclar Serum Ultra Concentrate
Obagi CLENZIderm MD Therapeutic Lotion
StriVectin STAR Light Retinol Night Oil 30ml
dermalogica Age Bright Spot Fader 15ml
L'OREAL Age Perfect Cell Renewal Regenerating Night Cream
Neutrogena Hydro Boost water gel
Neutrogena Micro-Mist
Murad Vitamin C Glycolic Brightening Serum
Garnier SkinActive BB Cream Anti-Aging Face Moisturizer, Light / Medium
Elizabeth Arden Advanced Ceramide Capsules Daily Youth Restoring Eye Serum-60piece


Storage: Store under room temperature. Avoid Heat & Light.

Shelf Life: 24Months from manufacturing or testing date (Current Lot will expire: 01/2025)

Dosage (Range): 1% - 10%

Recommended Dosage: 3%

Mix Method: Please follow instruction under product info carefully.

Heat Resistance: Avoid heat above 80C

Stable in pH range: 3 - 9

Solubility: Water , Oil , Most glycols , Ethanol, organic solvents , Soluble/Miscible in silicone

INCI: Dimethyl Isosorbide

Product Specification:

Test Specification
Appearance Clear, colorless liquid
Refractive Index 1.4580 - 1.4620
Specific Weight 1.15-1.17
Water Not more than 0.1%
Acid Value Not more than 1.5mgKOH/g
Heavy Metals 5ppm Max
Assay 99.0% Minimum


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