VER-246608
≥99%
- Product Code: 103183
CAS:
1684386-71-7
| Molecular Weight: | 552.96 g./mol | Molecular Formula: | C₂₈H₂₃ClF₂N₄O₄ |
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| Density: | Storage Condition: | 2-8℃ |
Product Description:
This compound is primarily investigated for its potential therapeutic applications, particularly in the field of oncology. It acts as an inhibitor of pyruvate dehydrogenase kinase (PDK), an enzyme that plays a critical role in cancer cell metabolism. By inhibiting PDK, it promotes the activity of pyruvate dehydrogenase, which shifts cellular metabolism from glycolysis to oxidative phosphorylation. This metabolic reprogramming can impair the growth and survival of cancer cells, especially those reliant on aerobic glycolysis, a phenomenon known as the Warburg effect. Research suggests it may enhance the efficacy of other cancer treatments, such as chemotherapy or radiotherapy, by sensitizing cancer cells to these therapies. Additionally, its role in modulating metabolism makes it a candidate for studying metabolic disorders and diseases where altered energy metabolism is a key factor.
Sizes / Availability / Pricing:
| Size (g) | Availability | Price | Quantity |
|---|---|---|---|
| 0.001 | 10-20 days | ฿19,080.00 |
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| 0.005 | 10-20 days | ฿39,168.00 |
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VER-246608
This compound is primarily investigated for its potential therapeutic applications, particularly in the field of oncology. It acts as an inhibitor of pyruvate dehydrogenase kinase (PDK), an enzyme that plays a critical role in cancer cell metabolism. By inhibiting PDK, it promotes the activity of pyruvate dehydrogenase, which shifts cellular metabolism from glycolysis to oxidative phosphorylation. This metabolic reprogramming can impair the growth and survival of cancer cells, especially those reliant on aerobic glycolysis, a phenomenon known as the Warburg effect. Research suggests it may enhance the efficacy of other cancer treatments, such as chemotherapy or radiotherapy, by sensitizing cancer cells to these therapies. Additionally, its role in modulating metabolism makes it a candidate for studying metabolic disorders and diseases where altered energy metabolism is a key factor.
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