Mertansine(DM1)

≥98%

  • Product Code: 103505
  CAS:    139504-50-0
Molecular Weight: 738.29 g./mol Molecular Formula: C₃₅H₄₈ClN₃O₁₀S
EC Number: MDL Number:
Melting Point: Boiling Point:
Density: Storage Condition: -20℃
Product Description: Mertansine (DM1) is primarily used as a potent cytotoxic agent in antibody-drug conjugates (ADCs) for targeted cancer therapy. It is conjugated to monoclonal antibodies that specifically recognize and bind to antigens on the surface of cancer cells. Once the ADC binds to the target cell, it is internalized, and DM1 is released, disrupting microtubule assembly and leading to cell cycle arrest and apoptosis. This targeted approach minimizes damage to healthy cells, making it effective in treating various cancers, including breast cancer and other solid tumors. Its application is particularly notable in drugs like trastuzumab emtansine (T-DM1), used for HER2-positive breast cancer.
Product Specification:
Test Specification
Appearance White To Off-White Solid
Purity (%) 97.5-100
Infrared Spectrum Conforms To Structure
NMR Conforms To Structure
Sizes / Availability / Pricing:
Size (g) Availability Price Quantity
0.005 10-20 days ฿6,500.00
+
-
0.010 10-20 days ฿12,200.00
+
-
0.025 10-20 days ฿24,000.00
+
-
0.100 10-20 days ฿65,000.00
+
-
Mertansine(DM1)
Mertansine (DM1) is primarily used as a potent cytotoxic agent in antibody-drug conjugates (ADCs) for targeted cancer therapy. It is conjugated to monoclonal antibodies that specifically recognize and bind to antigens on the surface of cancer cells. Once the ADC binds to the target cell, it is internalized, and DM1 is released, disrupting microtubule assembly and leading to cell cycle arrest and apoptosis. This targeted approach minimizes damage to healthy cells, making it effective in treating various cancers, including breast cancer and other solid tumors. Its application is particularly notable in drugs like trastuzumab emtansine (T-DM1), used for HER2-positive breast cancer.
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