Weinreb Linker
98%
- Product Code: 105967
Alias:
Weinleb linker; N-fluorenylmethoxycarbonyl-N-methoxy-3-alanine
CAS:
247021-90-5
| Molecular Weight: | 341.36 g./mol | Molecular Formula: | C₁₉H₁₉NO₅ |
|---|---|---|---|
| EC Number: | MDL Number: | ||
| Melting Point: | Boiling Point: | ||
| Density: | 1.294 | Storage Condition: | 2~8°C |
Product Description:
The Weinreb Linker is widely used in organic synthesis, particularly in the preparation of amides and ketones. It serves as a versatile intermediate, enabling the controlled transformation of carboxylic acids into Weinreb amides. These amides are highly valuable because they react selectively with organometallic reagents, such as Grignard or organolithium compounds, to produce ketones without over-reduction to alcohols. This specificity makes it a crucial tool in the synthesis of complex molecules, including pharmaceuticals, natural products, and fine chemicals. Additionally, the Weinreb Linker is employed in peptide chemistry for the selective coupling of amino acids, enhancing the efficiency of peptide bond formation. Its stability and reactivity profile make it a preferred choice in multi-step synthetic routes.
Product Specification:
| Test | Specification |
|---|---|
| Melting Point | 95 Degree Celsius-103 Degree Celsius |
| Purity (HPLC) | 98-100 |
| Appearance | White To Light Yellow Powder |
| ESI | Complies |
| Infrared Spectrometry | Conforms To Structure |
Sizes / Availability / Pricing:
| Size (g) | Availability | Price | Quantity |
|---|---|---|---|
| 1.000 | 10-20 days | $44.15 |
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| 5.000 | 10-20 days | $126.33 |
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| 25.000 | 10-20 days | $405.77 |
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| 100.000 | 10-20 days | $1,206.04 |
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Weinreb Linker
The Weinreb Linker is widely used in organic synthesis, particularly in the preparation of amides and ketones. It serves as a versatile intermediate, enabling the controlled transformation of carboxylic acids into Weinreb amides. These amides are highly valuable because they react selectively with organometallic reagents, such as Grignard or organolithium compounds, to produce ketones without over-reduction to alcohols. This specificity makes it a crucial tool in the synthesis of complex molecules, including pharmaceuticals, natural products, and fine chemicals. Additionally, the Weinreb Linker is employed in peptide chemistry for the selective coupling of amino acids, enhancing the efficiency of peptide bond formation. Its stability and reactivity profile make it a preferred choice in multi-step synthetic routes.
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