CRBN-6-5-5-VHL
≥95%
- Product Code: 106154
CAS:
2362575-45-7
| Molecular Weight: | 972.20 g./mol | Molecular Formula: | C₅₁H₆₉N₇O₁₀S |
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| Density: | Storage Condition: | -20°C, dry, sealed |
Product Description:
This compound is primarily utilized in the field of targeted protein degradation, particularly in the development of PROTACs (Proteolysis Targeting Chimeras). It serves as a key component in designing molecules that can selectively degrade disease-causing proteins by recruiting E3 ubiquitin ligases, such as VHL (Von Hippel-Lindau), to tag the target proteins for proteasomal destruction. Its application is significant in cancer research, where it helps in degrading oncogenic proteins that are otherwise difficult to target with traditional small-molecule inhibitors. Additionally, it is explored in neurodegenerative diseases and other conditions driven by aberrant protein accumulation. Its role in advancing precision medicine and drug discovery is notable, offering a novel approach to tackling previously undruggable targets.
Sizes / Availability / Pricing:
| Size (g) | Availability | Price | Quantity |
|---|---|---|---|
| 0.005 | 10-20 days | $1,080.11 |
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CRBN-6-5-5-VHL
This compound is primarily utilized in the field of targeted protein degradation, particularly in the development of PROTACs (Proteolysis Targeting Chimeras). It serves as a key component in designing molecules that can selectively degrade disease-causing proteins by recruiting E3 ubiquitin ligases, such as VHL (Von Hippel-Lindau), to tag the target proteins for proteasomal destruction. Its application is significant in cancer research, where it helps in degrading oncogenic proteins that are otherwise difficult to target with traditional small-molecule inhibitors. Additionally, it is explored in neurodegenerative diseases and other conditions driven by aberrant protein accumulation. Its role in advancing precision medicine and drug discovery is notable, offering a novel approach to tackling previously undruggable targets.
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