Ac-IETD-AFC (N-Acetyl-Ile-Glu-Thr-Asp-7-amino-4-Trifluoromethylcoumarin)
98%
- Product Code: 107479
CAS:
211990-57-7
| Molecular Weight: | 729.7 g./mol | Molecular Formula: | C₃₁H₃₈F₃N₅O₁₂ |
|---|---|---|---|
| EC Number: | MDL Number: | ||
| Melting Point: | Boiling Point: | ||
| Density: | Storage Condition: | -20°C, airtight, dry |
Product Description:
Ac-IETD-AFC is widely used as a fluorogenic substrate in biochemical research to study caspase-8 activity, a key enzyme involved in apoptosis (programmed cell death). It is particularly useful in assays designed to measure the activation and inhibition of caspase-8 in cellular and enzymatic studies. When cleaved by caspase-8, the substrate releases a fluorescent compound, 7-amino-4-trifluoromethylcoumarin (AFC), which can be detected and quantified using fluorescence spectroscopy. This allows researchers to monitor caspase-8 activity in real-time, providing insights into apoptotic pathways and the effects of potential therapeutic agents. Its high sensitivity and specificity make it a valuable tool in drug discovery and cancer research, where understanding apoptosis regulation is critical.
Product Specification:
| Test | Specification |
|---|---|
| Appearance | Solid |
| Purity (%) | 97.5-100 |
| Infrared Spectrum | Conforms To Structure |
| NMR | Conforms To Structure |
Sizes / Availability / Pricing:
| Size (g) | Availability | Price | Quantity |
|---|---|---|---|
| 0.005 | 10-20 days | ฿33,600.00 |
+
-
|
Ac-IETD-AFC (N-Acetyl-Ile-Glu-Thr-Asp-7-amino-4-Trifluoromethylcoumarin)
Ac-IETD-AFC is widely used as a fluorogenic substrate in biochemical research to study caspase-8 activity, a key enzyme involved in apoptosis (programmed cell death). It is particularly useful in assays designed to measure the activation and inhibition of caspase-8 in cellular and enzymatic studies. When cleaved by caspase-8, the substrate releases a fluorescent compound, 7-amino-4-trifluoromethylcoumarin (AFC), which can be detected and quantified using fluorescence spectroscopy. This allows researchers to monitor caspase-8 activity in real-time, providing insights into apoptotic pathways and the effects of potential therapeutic agents. Its high sensitivity and specificity make it a valuable tool in drug discovery and cancer research, where understanding apoptosis regulation is critical.
| Mechanism | - |
| Appearance | - |
| Longevity | - |
| Strength | - |
| Storage | - |
| Shelf Life | - |
| Allergen(s) | - |
| Dosage (Range) | - |
| Recommended Dosage | - |
| Dosage (Per Day) | - |
| Recommended Dosage (Per Day) | - |
| Mix Method | - |
| Heat Resistance | - |
| Stable in pH range | - |
| Solubility | - |
| Product Types | - |
| INCI | - |
Cart
No products
Subtotal:
฿0.00
฿0.00
Total :