N-p-Tosyl-L-phenylalanine chloromethyl ketone (TPCK)
97%
- Product Code: 110645
Alias:
TPCK
CAS:
402-71-1
| Molecular Weight: | 351.85 g./mol | Molecular Formula: | C₁₇H₁₈ClNO₃S |
|---|---|---|---|
| EC Number: | 206-954-6 | MDL Number: | MFCD00000935 |
| Melting Point: | 106-108 °C(lit.) | Boiling Point: | |
| Density: | Storage Condition: | -20°C |
Product Description:
TPCK is widely used in biochemical research as a specific inhibitor for serine proteases, particularly chymotrypsin. It works by alkylating the histidine residue in the active site of the enzyme, effectively blocking its activity. This property makes TPCK a valuable tool for studying the role of chymotrypsin-like enzymes in various biological processes, including protein digestion, blood clotting, and immune responses. Additionally, TPCK is employed in cell culture studies to investigate apoptosis and cell signaling pathways, as it can inhibit proteases involved in these processes. Its specificity and effectiveness in inhibiting serine proteases have made it a key reagent in enzymology and molecular biology research.
Product Specification:
| Test | Specification |
|---|---|
| Appearance | White Ro Almost White Crystal Or Powder |
| Purity (%) | 96.5-100 |
| Melting Point | 106.0-110.0 |
| Infrared Spectrum | Conforms To Structure |
| Specific Rotation [a]20/D (C=1, EtOH) | -87.0- -91.0 |
Sizes / Availability / Pricing:
| Size (g) | Availability | Price | Quantity |
|---|---|---|---|
| 0.025 | 10-20 days | ฿790.00 |
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| 0.100 | 10-20 days | ฿2,590.00 |
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| 0.250 | 10-20 days | ฿6,180.00 |
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N-p-Tosyl-L-phenylalanine chloromethyl ketone (TPCK)
TPCK is widely used in biochemical research as a specific inhibitor for serine proteases, particularly chymotrypsin. It works by alkylating the histidine residue in the active site of the enzyme, effectively blocking its activity. This property makes TPCK a valuable tool for studying the role of chymotrypsin-like enzymes in various biological processes, including protein digestion, blood clotting, and immune responses. Additionally, TPCK is employed in cell culture studies to investigate apoptosis and cell signaling pathways, as it can inhibit proteases involved in these processes. Its specificity and effectiveness in inhibiting serine proteases have made it a key reagent in enzymology and molecular biology research.
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