Azido-PEG3-Val-Cit-PAB-PNP
98%
- Product Code: 121088
CAS:
2055047-18-0
| Molecular Weight: | 773.79 g./mol | Molecular Formula: | C₃₄H₄₇N₉O₁₂ |
|---|---|---|---|
| EC Number: | MDL Number: | ||
| Melting Point: | Boiling Point: | ||
| Density: | Storage Condition: | 2-8°C |
Product Description:
This compound is primarily utilized in the development of antibody-drug conjugates (ADCs), where it serves as a linker to connect cytotoxic drugs to antibodies. The azide group enables click chemistry reactions, facilitating efficient and selective conjugation. The Val-Cit dipeptide sequence is cleavable by cathepsin B, an enzyme overexpressed in many cancer cells, allowing for targeted drug release. The PAB (para-aminobenzyl) spacer enhances the stability of the linker, while the PNP (p-nitrophenyl) group acts as a leaving group during the conjugation process. This design ensures precise delivery of therapeutic agents to cancer cells, minimizing off-target effects and improving treatment efficacy.
Product Specification:
| Test | Specification |
|---|---|
| Appearance | Yellow Solid |
| Purity (%) | 97.5-100 |
| Infrared Spectrum | Conforms To Structure |
| NMR | Conforms To Structure |
Sizes / Availability / Pricing:
| Size (g) | Availability | Price | Quantity |
|---|---|---|---|
| 0.005 | 10-20 days | £832.31 |
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Azido-PEG3-Val-Cit-PAB-PNP
This compound is primarily utilized in the development of antibody-drug conjugates (ADCs), where it serves as a linker to connect cytotoxic drugs to antibodies. The azide group enables click chemistry reactions, facilitating efficient and selective conjugation. The Val-Cit dipeptide sequence is cleavable by cathepsin B, an enzyme overexpressed in many cancer cells, allowing for targeted drug release. The PAB (para-aminobenzyl) spacer enhances the stability of the linker, while the PNP (p-nitrophenyl) group acts as a leaving group during the conjugation process. This design ensures precise delivery of therapeutic agents to cancer cells, minimizing off-target effects and improving treatment efficacy.
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