tert-Butyl 1-(fluorosulfonyl)azetidine-3-carboxylate
97%
- Product Code: 129793
CAS:
2757731-72-7
| Molecular Weight: | 239.26 g./mol | Molecular Formula: | C₈H₁₄FNO₄S |
|---|---|---|---|
| EC Number: | MDL Number: | ||
| Melting Point: | Boiling Point: | 305.9±52.0 °C(Predicted) | |
| Density: | 1.34±0.1 g/cm3(Predicted) | Storage Condition: | 2-8°C, Sealed, Inert Gas |
Product Description:
Used as a key intermediate in the synthesis of fluorinated pharmaceuticals, particularly in the development of bioactive molecules that benefit from enhanced metabolic stability and membrane permeability due to the fluorine atom. Its strained azetidine ring and reactive fluorosulfonyl group make it valuable in ring-expansion reactions and in the preparation of sulfonamide derivatives through SuFEx (Sulfur(VI) Fluoride Exchange) click chemistry. Commonly employed in medicinal chemistry for late-stage functionalization and in the design of enzyme inhibitors where the azetidine scaffold improves pharmacokinetic properties.
Sizes / Availability / Pricing:
| Size | Availability | Price | Quantity |
|---|---|---|---|
| 100mg | 10-20 days | ฿2,630.00 |
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| 250mg | 10-20 days | ฿4,450.00 |
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tert-Butyl 1-(fluorosulfonyl)azetidine-3-carboxylate
Used as a key intermediate in the synthesis of fluorinated pharmaceuticals, particularly in the development of bioactive molecules that benefit from enhanced metabolic stability and membrane permeability due to the fluorine atom. Its strained azetidine ring and reactive fluorosulfonyl group make it valuable in ring-expansion reactions and in the preparation of sulfonamide derivatives through SuFEx (Sulfur(VI) Fluoride Exchange) click chemistry. Commonly employed in medicinal chemistry for late-stage functionalization and in the design of enzyme inhibitors where the azetidine scaffold improves pharmacokinetic properties.
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