tert-Butyldimethylsilyl 2-bromoacetate
95%
- Product Code: 130394
CAS:
480439-46-1
| Molecular Weight: | 253.21 g./mol | Molecular Formula: | C₈H₁₇BrO₂Si |
|---|---|---|---|
| EC Number: | MDL Number: | MFCD04039979 | |
| Melting Point: | 175-189 °C | Boiling Point: | |
| Density: | Storage Condition: | 2-8°C, Sealed, Inert Gas |
Product Description:
Used as a silyl protecting group reagent in organic synthesis, particularly in the protection of alcohols and hydroxyl groups during multi-step synthesis of complex molecules such as natural products and pharmaceuticals. The tert-butyldimethylsilyl (TBS) group provides stability under a variety of reaction conditions while being selectively removable under mild acidic or fluoride ion conditions. The presence of the 2-bromoacetate moiety allows for further functionalization, enabling the introduction of bromoalkyl units that can participate in subsequent alkylation or cyclization reactions. Commonly employed in carbohydrate chemistry and nucleoside synthesis where selective protection is critical. Its reactivity also makes it useful in the preparation of bifunctional intermediates for medicinal chemistry and polymer synthesis.
Sizes / Availability / Pricing:
| Size | Availability | Price | Quantity |
|---|---|---|---|
| 1.000 | 10-20 days | $312.71 |
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| 0.250 | 10-20 days | $116.22 |
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tert-Butyldimethylsilyl 2-bromoacetate
Used as a silyl protecting group reagent in organic synthesis, particularly in the protection of alcohols and hydroxyl groups during multi-step synthesis of complex molecules such as natural products and pharmaceuticals. The tert-butyldimethylsilyl (TBS) group provides stability under a variety of reaction conditions while being selectively removable under mild acidic or fluoride ion conditions. The presence of the 2-bromoacetate moiety allows for further functionalization, enabling the introduction of bromoalkyl units that can participate in subsequent alkylation or cyclization reactions. Commonly employed in carbohydrate chemistry and nucleoside synthesis where selective protection is critical. Its reactivity also makes it useful in the preparation of bifunctional intermediates for medicinal chemistry and polymer synthesis.
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