2-(2,6-Dioxopiperidin-3-yl)-1-oxoisoindoline-5-carboxylic acid
97%
- Product Code: 130707
CAS:
2171780-01-9
| Molecular Weight: | 288.26 g./mol | Molecular Formula: | C₁₄H₁₂N₂O₅ |
|---|---|---|---|
| EC Number: | MDL Number: | MFCD31735773 | |
| Melting Point: | Boiling Point: | 667.4±55.0 °C(Predicted) | |
| Density: | 1.535±0.06 g/cm3(Predicted) | Storage Condition: | Room temperature, light-proof, inert gas |
Product Description:
Used primarily in pharmaceutical research as a key intermediate in the synthesis of immunomodulatory drugs, particularly analogs of thalidomide such as lenalidomide. It plays a critical role in targeted protein degradation therapies, including the development of cereblon E3 ligase modulators. These compounds are investigated for their anticancer, anti-inflammatory, and antiproliferative properties, especially in hematological malignancies like multiple myeloma and myelodysplastic syndromes. Its structure enables selective binding to cereblon, facilitating the degradation of disease-causing proteins. Widely utilized in medicinal chemistry for designing PROTACs (proteolysis-targeting chimeras) and optimizing drug candidates with improved efficacy and safety profiles.
Sizes / Availability / Pricing:
| Size | Availability | Price | Quantity |
|---|---|---|---|
| 100mg | 10-20 days | ฿5,050.00 |
+
-
|
| 250mg | 10-20 days | ฿9,590.00 |
+
-
|
| 1g | 10-20 days | ฿28,740.00 |
+
-
|
2-(2,6-Dioxopiperidin-3-yl)-1-oxoisoindoline-5-carboxylic acid
Used primarily in pharmaceutical research as a key intermediate in the synthesis of immunomodulatory drugs, particularly analogs of thalidomide such as lenalidomide. It plays a critical role in targeted protein degradation therapies, including the development of cereblon E3 ligase modulators. These compounds are investigated for their anticancer, anti-inflammatory, and antiproliferative properties, especially in hematological malignancies like multiple myeloma and myelodysplastic syndromes. Its structure enables selective binding to cereblon, facilitating the degradation of disease-causing proteins. Widely utilized in medicinal chemistry for designing PROTACs (proteolysis-targeting chimeras) and optimizing drug candidates with improved efficacy and safety profiles.
| Mechanism | - |
| Appearance | - |
| Longevity | - |
| Strength | - |
| Storage | - |
| Shelf Life | - |
| Allergen(s) | - |
| Dosage (Range) | - |
| Recommended Dosage | - |
| Dosage (Per Day) | - |
| Recommended Dosage (Per Day) | - |
| Mix Method | - |
| Heat Resistance | - |
| Stable in pH range | - |
| Solubility | - |
| Product Types | - |
| INCI | - |
Purchase History for
Loading purchase history...
Cart
No products
Subtotal:
฿0.00
฿0.00
Total :