AZD-2858
99%
- Product Code: 135096
Alias:
3-amino-6-[4-[(4-methyl-1-piperazinyl)sulfonyl]phenyl]-N-3-pyridyl-pyrazincarboxamide; 3-amino-6-[4-(4-methylpiperazin-1-yl)sulfonylphenyl]-N-pyridyl-3-ylpyrazin-2-carboxamide
CAS:
486424-20-8
| Molecular Weight: | 453.52 g./mol | Molecular Formula: | C₂₁H₂₃N₇O₃S |
|---|---|---|---|
| EC Number: | MDL Number: | MFCD26397072 | |
| Melting Point: | Boiling Point: | ||
| Density: | Storage Condition: | -20°C |
Product Description:
AZD-2858 is a potent and selective inhibitor of glycogen synthase kinase-3 (GSK-3), an enzyme involved in multiple signaling pathways related to cell survival, inflammation, and metabolism. Its primary application lies in research settings for studying diseases where GSK-3 overactivity is implicated, such as neurodegenerative disorders including Alzheimer's disease. By inhibiting GSK-3, AZD-2858 helps reduce the hyperphosphorylation of tau protein, a key pathological feature in Alzheimer's, making it a valuable tool in preclinical models for evaluating potential neuroprotective strategies.
It has also been explored in studies related to mood disorders and bipolar disease due to GSK-3's role in regulating neuronal plasticity and behavior. Additionally, AZD-2858 shows potential in research on inflammatory conditions and diabetes, where modulation of GSK-3 can influence insulin signaling and inflammatory cytokine production. Due to its research-focused use, AZD-2858 is primarily applied in cellular and animal models to assess therapeutic pathways rather than in clinical treatment.
Sizes / Availability / Pricing:
| Size | Availability | Price | Quantity |
|---|---|---|---|
| 5mg | 10-20 days | ฿6,170.00 |
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| 25mg | 10-20 days | ฿17,800.00 |
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AZD-2858
AZD-2858 is a potent and selective inhibitor of glycogen synthase kinase-3 (GSK-3), an enzyme involved in multiple signaling pathways related to cell survival, inflammation, and metabolism. Its primary application lies in research settings for studying diseases where GSK-3 overactivity is implicated, such as neurodegenerative disorders including Alzheimer's disease. By inhibiting GSK-3, AZD-2858 helps reduce the hyperphosphorylation of tau protein, a key pathological feature in Alzheimer's, making it a valuable tool in preclinical models for evaluating potential neuroprotective strategies.
It has also been explored in studies related to mood disorders and bipolar disease due to GSK-3's role in regulating neuronal plasticity and behavior. Additionally, AZD-2858 shows potential in research on inflammatory conditions and diabetes, where modulation of GSK-3 can influence insulin signaling and inflammatory cytokine production. Due to its research-focused use, AZD-2858 is primarily applied in cellular and animal models to assess therapeutic pathways rather than in clinical treatment.
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