Alloc-Val-Cit-PAB-OH

≥96%(LC&N)

Product Code: 137289

CAS: 1608127-09-8

Molecular Weight:	463.54 g./mol	Molecular Formula:	C₂₂H₃₃N₅O₆
EC Number:		MDL Number:
Melting Point:	207 °C(dec.)	Boiling Point:
Density:		Storage Condition:	-20°C

Product Description: Used as a linker in antibody-drug conjugates (ADCs), enabling targeted delivery of cytotoxic agents to cancer cells. The dipeptide Val-Cit is cleavable by cathepsin B, an enzyme overexpressed in tumor tissues, allowing selective release of the drug inside cancer cells. The PAB (para-aminobenzyloxycarbonyl) spacer facilitates efficient drug release upon cleavage, while the Alloc (allyloxycarbonyl) group serves as a protecting group during synthesis, which can be selectively removed under mild conditions. This linker system enhances the stability of ADCs in circulation and improves therapeutic index by minimizing off-target toxicity.

Sizes / Availability / Pricing:

Size	Availability	Price	Quantity
0.100	10-20 days	฿12,850.00	+ -

Alloc-Val-Cit-PAB-OH

Used as a linker in antibody-drug conjugates (ADCs), enabling targeted delivery of cytotoxic agents to cancer cells. The dipeptide Val-Cit is cleavable by cathepsin B, an enzyme overexpressed in tumor tissues, allowing selective release of the drug inside cancer cells. The PAB (para-aminobenzyloxycarbonyl) spacer facilitates efficient drug release upon cleavage, while the Alloc (allyloxycarbonyl) group serves as a protecting group during synthesis, which can be selectively removed under mild conditions. This linker system enhances the stability of ADCs in circulation and improves therapeutic index by minimizing off-target toxicity.

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Alloc-Val-Cit-PAB-OH

≥96%(LC&N)

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