6-(1-Acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)nicotinamide
98%
- Product Code: 138454
CAS:
1655504-04-3
| Molecular Weight: | 427.5 g./mol | Molecular Formula: | C₂₆H₂₅N₃O₃ |
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| Density: | Storage Condition: | 2-8°C, dry |
Product Description:
Used in pharmaceutical research as a key intermediate in the synthesis of selective kinase inhibitors, particularly targeting tyrosine kinases involved in inflammatory and oncogenic signaling pathways. Its structure supports high binding affinity to specific enzyme active sites, making it valuable in developing treatments for autoimmune diseases and certain cancers. Also employed in the design of covalent inhibitors due to the acryloyl group, which enables irreversible binding to cysteine residues in target proteins. Additionally, it serves as a building block in medicinal chemistry for structure-activity relationship (SAR) studies to optimize drug potency and selectivity.
Sizes / Availability / Pricing:
| Size | Availability | Price | Quantity |
|---|---|---|---|
| 0.025 | 10-20 days | ฿8,310.00 |
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| 0.050 | 10-20 days | ฿14,110.00 |
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| 0.100 | 10-20 days | ฿25,220.00 |
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| 0.250 | 10-20 days | ฿50,000.00 |
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6-(1-Acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)nicotinamide
Used in pharmaceutical research as a key intermediate in the synthesis of selective kinase inhibitors, particularly targeting tyrosine kinases involved in inflammatory and oncogenic signaling pathways. Its structure supports high binding affinity to specific enzyme active sites, making it valuable in developing treatments for autoimmune diseases and certain cancers. Also employed in the design of covalent inhibitors due to the acryloyl group, which enables irreversible binding to cysteine residues in target proteins. Additionally, it serves as a building block in medicinal chemistry for structure-activity relationship (SAR) studies to optimize drug potency and selectivity.
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