Anti-TNFSF7 / CD27L / CD70 Reference Antibody (cusatuzumab)
- Product Code: 140611
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Product Description:
Used in the treatment of hematologic malignancies, particularly acute myeloid leukemia (AML) and certain B-cell lymphomas. It targets CD70 (CD27 ligand), which is overexpressed on cancer cells but limited in healthy tissues, enabling selective immune attack. By binding to CD70, it blocks the CD27-CD70 signaling pathway involved in tumor cell survival and immune evasion. This promotes antibody-dependent cellular cytotoxicity (ADCC) and supports T-cell activation, enhancing anti-tumor immune responses. Investigated in clinical trials as a monotherapy and in combination with other agents like hypomethylating drugs to improve outcomes in relapsed or refractory cancers.
Sizes / Availability / Pricing:
| Size | Availability | Price | Quantity |
|---|---|---|---|
| 50μg | 10-20 days | ฿4,980.00 |
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Anti-TNFSF7 / CD27L / CD70 Reference Antibody (cusatuzumab)
Used in the treatment of hematologic malignancies, particularly acute myeloid leukemia (AML) and certain B-cell lymphomas. It targets CD70 (CD27 ligand), which is overexpressed on cancer cells but limited in healthy tissues, enabling selective immune attack. By binding to CD70, it blocks the CD27-CD70 signaling pathway involved in tumor cell survival and immune evasion. This promotes antibody-dependent cellular cytotoxicity (ADCC) and supports T-cell activation, enhancing anti-tumor immune responses. Investigated in clinical trials as a monotherapy and in combination with other agents like hypomethylating drugs to improve outcomes in relapsed or refractory cancers.
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