5-chloro-2-(1-methyl-2,6-dioxopiperidin-3-yl)isoindole-1,3-dione
98%
- Product Code: 157560
| Molecular Weight: | 306.04 g./mol | Molecular Formula: | C₁₄H₁₁O₄ClN₂ |
|---|---|---|---|
| EC Number: | MDL Number: | ||
| Melting Point: | Boiling Point: | ||
| Density: | Storage Condition: | 2-8 °C, sealed, dry |
Product Description:
Used primarily as a key intermediate in the synthesis of immunomodulatory drugs, particularly in the development of cereblon E3 ligase modulators. It plays a critical role in the production of targeted protein degradation therapeutics, including analogs of lenalidomide and pomalidomide. Its structure enables selective binding to cereblon, facilitating the degradation of disease-causing proteins, making it valuable in oncology research, especially for hematological cancers like multiple myeloma and myelodysplastic syndromes. Also employed in the preparation of PROTACs (proteolysis-targeting chimeras) due to its ability to recruit E3 ubiquitin ligase.
Product Specification:
| Test | Specification |
|---|---|
| Appearance | Gray white solid |
| Purity (%) | 97.5-100 |
| Infrared Spectrum | Conforms to Structure |
| NMR | Conforms to Structure |
Sizes / Availability / Pricing:
| Size | Availability | Price | Quantity |
|---|---|---|---|
| 0.100 | 10-20 days | ฿5,760.00 |
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| 0.250 | 10-20 days | ฿11,520.00 |
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5-chloro-2-(1-methyl-2,6-dioxopiperidin-3-yl)isoindole-1,3-dione
Used primarily as a key intermediate in the synthesis of immunomodulatory drugs, particularly in the development of cereblon E3 ligase modulators. It plays a critical role in the production of targeted protein degradation therapeutics, including analogs of lenalidomide and pomalidomide. Its structure enables selective binding to cereblon, facilitating the degradation of disease-causing proteins, making it valuable in oncology research, especially for hematological cancers like multiple myeloma and myelodysplastic syndromes. Also employed in the preparation of PROTACs (proteolysis-targeting chimeras) due to its ability to recruit E3 ubiquitin ligase.
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| Stable in pH range | - |
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| Product Types | - |
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