CX-5461
2mM in DMSO
- Product Code: 157737
CAS:
1138549-36-6
| Molecular Weight: | 513.61 g./mol | Molecular Formula: | C₂₇H₂₇N₇O₂S |
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| Density: | Storage Condition: | -20°C |
Product Description:
CX-5461 is primarily used in cancer research as a selective inhibitor of RNA polymerase I, which plays a key role in ribosomal RNA synthesis. By targeting this pathway, CX-5461 disrupts ribosome biogenesis in rapidly dividing cancer cells, leading to nucleolar stress and activation of p53-dependent and p53-independent tumor suppressor pathways. It has shown potent anti-tumor activity in hematological malignancies and certain solid tumors, especially in cancers with dysregulated MYC expression. Due to its unique mechanism of action, CX-5461 is being investigated in preclinical and early clinical trials as a potential therapeutic agent for cancers resistant to conventional treatments. Its ability to selectively target cancer cell transcription machinery without damaging DNA makes it a promising candidate for novel oncology therapies.
Sizes / Availability / Pricing:
| Size | Availability | Price | Quantity |
|---|---|---|---|
| 1ml | 10-20 days | ฿5,020.00 |
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CX-5461
CX-5461 is primarily used in cancer research as a selective inhibitor of RNA polymerase I, which plays a key role in ribosomal RNA synthesis. By targeting this pathway, CX-5461 disrupts ribosome biogenesis in rapidly dividing cancer cells, leading to nucleolar stress and activation of p53-dependent and p53-independent tumor suppressor pathways. It has shown potent anti-tumor activity in hematological malignancies and certain solid tumors, especially in cancers with dysregulated MYC expression. Due to its unique mechanism of action, CX-5461 is being investigated in preclinical and early clinical trials as a potential therapeutic agent for cancers resistant to conventional treatments. Its ability to selectively target cancer cell transcription machinery without damaging DNA makes it a promising candidate for novel oncology therapies.
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