CHIR-99021 (CT99021) HCl
10mM in DMSO
- Product Code: 157821
CAS:
1797989-42-4
| Molecular Weight: | 501.8 g./mol | Molecular Formula: | C₂₂H₁₈Cl₂N₈·HCl |
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| Density: | Storage Condition: | -20°C |
Product Description:
CHIR-99021 HCl is a potent and selective inhibitor of GSK-3α and GSK-3β kinases. It is widely used in stem cell research to support the maintenance of pluripotency in embryonic stem cells by activating the Wnt signaling pathway. By inhibiting GSK-3, it stabilizes β-catenin, which promotes self-renewal and prevents spontaneous differentiation. It is commonly included in culture media formulations for human and mouse pluripotent stem cells, especially in feeder-free or defined culture systems. CHIR-99021 HCl is also used in reprogramming somatic cells into induced pluripotent stem cells (iPSCs), where it enhances reprogramming efficiency. Additionally, it plays a role in directed differentiation protocols, particularly in cardiac and neural differentiation, due to its ability to modulate key developmental pathways. Its high selectivity and cell permeability make it a valuable tool in regenerative medicine and drug discovery research.
Sizes / Availability / Pricing:
| Size | Availability | Price | Quantity |
|---|---|---|---|
| 1ml | 10-20 days | ฿6,740.00 |
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CHIR-99021 (CT99021) HCl
CHIR-99021 HCl is a potent and selective inhibitor of GSK-3α and GSK-3β kinases. It is widely used in stem cell research to support the maintenance of pluripotency in embryonic stem cells by activating the Wnt signaling pathway. By inhibiting GSK-3, it stabilizes β-catenin, which promotes self-renewal and prevents spontaneous differentiation. It is commonly included in culture media formulations for human and mouse pluripotent stem cells, especially in feeder-free or defined culture systems. CHIR-99021 HCl is also used in reprogramming somatic cells into induced pluripotent stem cells (iPSCs), where it enhances reprogramming efficiency. Additionally, it plays a role in directed differentiation protocols, particularly in cardiac and neural differentiation, due to its ability to modulate key developmental pathways. Its high selectivity and cell permeability make it a valuable tool in regenerative medicine and drug discovery research.
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