CB-5083
10mM in DMSO
- Product Code: 157828
CAS:
1542705-92-9
| Molecular Weight: | 413.47 g./mol | Molecular Formula: | C₂₄H₂₃N₅O₂ |
|---|---|---|---|
| EC Number: | MDL Number: | MFCD28963914 | |
| Melting Point: | Boiling Point: | ||
| Density: | Storage Condition: | -20°C |
Product Description:
CB-5083 is a potent and selective inhibitor of p97 (also known as VCP), a key ATPase involved in the ubiquitin-proteasome system. It disrupts protein homeostasis by blocking the degradation of ubiquitinated proteins, leading to endoplasmic reticulum stress and activation of the unfolded protein response. This mechanism makes CB-5083 a promising candidate in cancer therapy, particularly for tumors reliant on efficient protein clearance, such as multiple myeloma and certain solid tumors. In preclinical studies, CB-5083 has shown antitumor activity by inducing apoptosis in cancer cells. Its ability to target the p97 pathway offers a novel approach in oncology, especially for cancers resistant to proteasome inhibitors. Research continues to explore its efficacy and potential in combination therapies.
Sizes / Availability / Pricing:
| Size | Availability | Price | Quantity |
|---|---|---|---|
| 1ml | 10-20 days | ฿3,980.00 |
+
-
|
CB-5083
CB-5083 is a potent and selective inhibitor of p97 (also known as VCP), a key ATPase involved in the ubiquitin-proteasome system. It disrupts protein homeostasis by blocking the degradation of ubiquitinated proteins, leading to endoplasmic reticulum stress and activation of the unfolded protein response. This mechanism makes CB-5083 a promising candidate in cancer therapy, particularly for tumors reliant on efficient protein clearance, such as multiple myeloma and certain solid tumors. In preclinical studies, CB-5083 has shown antitumor activity by inducing apoptosis in cancer cells. Its ability to target the p97 pathway offers a novel approach in oncology, especially for cancers resistant to proteasome inhibitors. Research continues to explore its efficacy and potential in combination therapies.
| Mechanism | - |
| Appearance | - |
| Longevity | - |
| Strength | - |
| Storage | - |
| Shelf Life | - |
| Allergen(s) | - |
| Dosage (Range) | - |
| Recommended Dosage | - |
| Dosage (Per Day) | - |
| Recommended Dosage (Per Day) | - |
| Mix Method | - |
| Heat Resistance | - |
| Stable in pH range | - |
| Solubility | - |
| Product Types | - |
| INCI | - |
Purchase History for
Loading purchase history...
Cart
No products
Subtotal:
฿0.00
฿0.00
Total :