Fmoc-Val-D-Cit-PAB
98%
- Product Code: 186618
CAS:
1350456-67-5
Molecular Weight: | 601.69 g./mol | Molecular Formula: | C₃₃H₃₉N₅O₆ |
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Density: | Storage Condition: | -20°C |
Product Description:
Used in the synthesis of antibody-drug conjugates (ADCs) as a linker-payload component. The Fmoc-Val-D-Cit-PAB structure incorporates a self-immolative spacer (PAB) that enables controlled release of cytotoxic agents upon specific biological triggers, such as enzymatic cleavage. The D-Cit (diaminopropionic acid derivative) enhances stability and solubility during conjugation processes, while the Fmoc group allows for solid-phase peptide synthesis compatibility. This compound is particularly valuable in developing targeted cancer therapies where precise drug activation is critical.
Sizes / Availability / Pricing:
Size | Availability | Price | Quantity |
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50mg | 10-20 days | ฿49,340.00 |
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Fmoc-Val-D-Cit-PAB
Used in the synthesis of antibody-drug conjugates (ADCs) as a linker-payload component. The Fmoc-Val-D-Cit-PAB structure incorporates a self-immolative spacer (PAB) that enables controlled release of cytotoxic agents upon specific biological triggers, such as enzymatic cleavage. The D-Cit (diaminopropionic acid derivative) enhances stability and solubility during conjugation processes, while the Fmoc group allows for solid-phase peptide synthesis compatibility. This compound is particularly valuable in developing targeted cancer therapies where precise drug activation is critical.
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