Fmoc-PEG3-Ala-Ala-Asn(Trt)-PAB
95%
- Product Code: 186620
CAS:
2055042-69-6
| Molecular Weight: | 1047.22 g./mol | Molecular Formula: | C₆₀H₆₆N₆O₁₁ |
|---|---|---|---|
| EC Number: | MDL Number: | MFCD30182025 | |
| Melting Point: | Boiling Point: | ||
| Density: | Storage Condition: | -20°C |
Product Description:
Used in antibody-drug conjugate (ADC) development as a linker-payload component. The PEG3 spacer enhances solubility and flexibility, improving conjugation efficiency and stability. Fmoc group allows for controlled deprotection in solid-phase synthesis, enabling stepwise assembly. The Ala-Ala-Asn(Trt) sequence serves as a cathepsin-cleavable dipeptide substrate, facilitating targeted drug release inside lysosomes. PAB (para-aminobenzyl alcohol) acts as a self-immolative spacer, releasing the active drug upon cleavage. Commonly employed in constructing prodrugs and bioconjugates where enzyme-triggered payload release is required.
Sizes / Availability / Pricing:
| Size | Availability | Price | Quantity |
|---|---|---|---|
| 25mg | 10-20 days | ฿41,450.00 |
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Fmoc-PEG3-Ala-Ala-Asn(Trt)-PAB
Used in antibody-drug conjugate (ADC) development as a linker-payload component. The PEG3 spacer enhances solubility and flexibility, improving conjugation efficiency and stability. Fmoc group allows for controlled deprotection in solid-phase synthesis, enabling stepwise assembly. The Ala-Ala-Asn(Trt) sequence serves as a cathepsin-cleavable dipeptide substrate, facilitating targeted drug release inside lysosomes. PAB (para-aminobenzyl alcohol) acts as a self-immolative spacer, releasing the active drug upon cleavage. Commonly employed in constructing prodrugs and bioconjugates where enzyme-triggered payload release is required.
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