Folinic acid
10mM in DMSO
- Product Code: 186984
CAS:
58-05-9
| Molecular Weight: | 473.44 g./mol | Molecular Formula: | C₂₀H₂₃N₇O₇ |
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| Density: | Storage Condition: | -20°C |
Product Description:
Used as a rescue agent after high-dose methotrexate therapy to reduce toxicity while preserving anticancer effects. Enhances the therapeutic index of 5-fluorouracil in colorectal cancer by stabilizing the binding of fluorouracil’s active metabolite to thymidylate synthase. Employed in the treatment of megaloblastic anemia when oral folic acid absorption is impaired. Investigated in neurological disorders such as autism and cerebral folate deficiency due to its ability to cross the blood-brain barrier and support folate-dependent metabolic processes in the central nervous system.
Sizes / Availability / Pricing:
| Size | Availability | Price | Quantity |
|---|---|---|---|
| 1ml | 10-20 days | ฿1,850.00 |
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Folinic acid
Used as a rescue agent after high-dose methotrexate therapy to reduce toxicity while preserving anticancer effects. Enhances the therapeutic index of 5-fluorouracil in colorectal cancer by stabilizing the binding of fluorouracil’s active metabolite to thymidylate synthase. Employed in the treatment of megaloblastic anemia when oral folic acid absorption is impaired. Investigated in neurological disorders such as autism and cerebral folate deficiency due to its ability to cross the blood-brain barrier and support folate-dependent metabolic processes in the central nervous system.
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