Fmoc-Cit-PAB-OH
97%
- Product Code: 187971
CAS:
870487-04-0
| Molecular Weight: | 502.57 g./mol | Molecular Formula: | C₂₈H₃₀N₄O₅ |
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| Density: | Storage Condition: | 2-8°C |
Product Description:
Used in the synthesis of antibody-drug conjugates (ADCs), particularly as a linker-payload component. The PAB (para-aminobenzyloxycarbonyl) spacer enables controlled release of cytotoxic agents inside target cells through enzymatic cleavage, typically by cathepsin B. Fmoc-Cit-PAB-OH serves as a protected building block where the citrulline (Cit) residue provides a site for attachment and the Fmoc group allows for solid-phase peptide synthesis compatibility. Its main role is to bridge the antibody and the drug, ensuring stability in circulation and efficient drug release upon internalization into cancer cells.
Sizes / Availability / Pricing:
| Size | Availability | Price | Quantity |
|---|---|---|---|
| 250mg | 10-20 days | ฿3,610.00 |
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| 1g | 10-20 days | ฿7,750.00 |
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Fmoc-Cit-PAB-OH
Used in the synthesis of antibody-drug conjugates (ADCs), particularly as a linker-payload component. The PAB (para-aminobenzyloxycarbonyl) spacer enables controlled release of cytotoxic agents inside target cells through enzymatic cleavage, typically by cathepsin B. Fmoc-Cit-PAB-OH serves as a protected building block where the citrulline (Cit) residue provides a site for attachment and the Fmoc group allows for solid-phase peptide synthesis compatibility. Its main role is to bridge the antibody and the drug, ensuring stability in circulation and efficient drug release upon internalization into cancer cells.
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