2-(5-Fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidine-4,5,6-triamine
97%
- Product Code: 188691
Alias:
Vili watermelon intermediate; Vilisigua intermediate; Vilisigua intermediate; Leosigua intermediate
CAS:
1350653-30-3
| Molecular Weight: | 368.34 g./mol | Molecular Formula: | C₁₇H₁₄F₂N₈ |
|---|---|---|---|
| EC Number: | MDL Number: | MFCD26517131 | |
| Melting Point: | Boiling Point: | ||
| Density: | 1.49 at 20℃ | Storage Condition: | 2-8°C |
Product Description:
Used in research as a potent and selective inhibitor of anaplastic lymphoma kinase (ALK), particularly in the development of targeted cancer therapies. Shows promising activity against ALK-positive non-small cell lung cancer (NSCLC) by blocking abnormal signaling pathways that drive tumor growth. Also demonstrates effectiveness in overcoming resistance mutations in ALK, making it valuable in second-generation inhibitor design. Investigated for its blood-brain barrier penetration, supporting potential use in treating brain metastases associated with ALK-driven cancers. Currently utilized primarily in preclinical studies and drug development rather than clinical treatment.
Sizes / Availability / Pricing:
| Size | Availability | Price | Quantity |
|---|---|---|---|
| 1g | 10-20 days | ฿7,920.00 |
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| 5g | 10-20 days | ฿22,150.00 |
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2-(5-Fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidine-4,5,6-triamine
Used in research as a potent and selective inhibitor of anaplastic lymphoma kinase (ALK), particularly in the development of targeted cancer therapies. Shows promising activity against ALK-positive non-small cell lung cancer (NSCLC) by blocking abnormal signaling pathways that drive tumor growth. Also demonstrates effectiveness in overcoming resistance mutations in ALK, making it valuable in second-generation inhibitor design. Investigated for its blood-brain barrier penetration, supporting potential use in treating brain metastases associated with ALK-driven cancers. Currently utilized primarily in preclinical studies and drug development rather than clinical treatment.
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